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Dr.
 
Marius
 
REGLIER

Portrait de Dr. Marius Reglier
Dr.
Marius
REGLIER
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
13397
Marseille cedex 20


Téléphone
Fax
0491 28 84 40

Parcours

Education:
1975: Master in Sciences, Paul Cézanne Univ. Aix-Marseille III
1976: Chemical Ingeneer, Ecole Supérieure de Chimie de Marseille
1980: First Ph. D., Paul Cézanne Univ. Aix-Marseille III, September 26, 1980, Reactivity of non-conjugated dienes towards the catalytic system PdCl2/CuCl2: cyclisation and allylic oxidations (Pr. B. Waegell and Dr. A. Heumann)
1984: Second Ph. D. (thèse d’Etat), Pierre and Marie Curie Univ. Paris VI, December 18, 1984, Syntheses and Reactivity of Thia and 1-Aza-3-Cyclohexenes (Dr. S. Julia)

Experience:
1980-1984: CNRS Researcher (Attaché de Recherche), Ecole Normale Supérieure, Pierre and Marie Curie Univ. Paris VI, Dr. S. Julia
1985-1986: Research Fellow; University of Geneva, Switzerland, Pr. W. Oppolzer.
1986-1994: CNRS Researcher (CR1), Paul Cézanne Univ. Aix-Marseille III, Pr. B. Waegell
1989-1990: Research Fellow, Lab. of Cellular and Molecular Neurobiology, Gif/Yvette, Dr. J. Mallet.
1992: Visiting scientist, Johns Hopkins Univ., Baltimore, USA, Pr. K. D. Karlin.
1994-2018 : CNRS Researcher (DR2 then DR1), Aix-Marseille Université
2018-: CNRS Research Director emeritus (DREM)

Past administrative positions:
1996-2004: Member of the organising committee of REncontres de Chimie Organique Biologique (President for RECOB8, 2000)
2000-2004: Appointed member of the CNRS Comité National section 20
2001-2006: President of the GIS CNRS/Univ. Paul Cézanne Club CNRS Métalloprotéines et Modèles

2006-2011: Member of the scientific committee of the Indo-French Center for the Promotion of the Advanced Research (CEFIPRA/IFCPAR)
2006-2008: Creaction and Head of the FRE CNRS 3005 BiosCiences

2007-2009: Member of the scientific committee of the ANR program blanc
2009-2012: Vice-president of the ANR program Retour Post-doctorant
2009-2017: Head of the team BiosCiences
 (iSm2 UMR CNRS 7313)
2010-2015: French member of the Management Committee Action COST CM1003, Biological Oxidation Reactions, Mechanisms and Design of new Catalysts
2012-2018: Scientific officier at the Institut de Chimie du CNRS

Distinctions

2002: Docteur et de Madame Henri Labbé prize from the French Academy of Science.
2002: JSPS fellowship

2004: France Berkeley Fund with J. P. Klinman, Department of Chemistry UC Berkeley
2011: CNRS Excellence in Science
2014Chaire d’excellence from FAPESP (São Paulo Research Fondation) in University of São Paulo (USP).

Enseignements

Aix Marseille Université
- Synthetic biology, M2 degree course in Master Chemistry

Université Paris Descartes
- Redox bio-inorganic chemistry, M2 degree course in Master Frontiers in Chemistry

Ecole de l’INSERM Liliane Bettencourt, double degree course Medecine/Science
- Chemical aspects of Epigenetic, L2 course for medical students

  
 

- Chemistry of the S-Adenosyl Methionine cofactor (MOOC)

 The S-Adenosyl Methionine cofactor

 resolution.mpg

Thématiques

Activation of small molecules (O2, H2, H2O, CO2 …) by metalloenzymes and their biomimetic/bioinspired models.

A) Cu-containing monooxygenases (in collaboration with J. A. Simaan, M. Orio, B. Faure, R. Hardré and C. Decroos) 
Focused on Tyrosinase (Ty), Dopamine beta-Hydroxylase (DbH), Peptidylglycine alpha-Amidating Monooxygenase (PAM), particulate Methane MonoOxygenase (pMMO) and Lytic Polysaccharide MonoOxygenase (LPMO):

- Functional and structural metalloenzyme models
- Mechanism-based inhibitors of DbH, PAM and Ty
- Purification and genetic expression of copper-containing monooxygenases.

Selected publications on Tyrosinase inhibition: E. Peyroux et al. Inorg. Chem. 200948, 10874–10876 ; W. Yi et al. Eur. J. Chem. Med. 201146, 4330-4335 ; M. Orio et al. Chem. Eur. J. 201117, 13482–13494 ; C. Dubois et al. ChemBioChem 201213, 559-565 ; C. Bochot et alChem. Eur. J. 201319, 3655-3664 ; C. Bochot et al.Chem. Commun. 201450, 308-3010 ; R. Haudecoeur et alChemBioChem 2014,15(9), 1325–1333 ; E. Buitrago et al. Inorg. Chem. 201453, 12848-12858 ; E. Marková et al. J. Agr. Food Chem. 201664, 2925-2931 ; E. Buitrago et al. Current Topics in Medicinal Chemistry 201616(27), 3033-3047 ; R. Haudecoeur et al. ACS Med. Chem. Lett. 2017, 8 (1), 55-60.

Selected publications on copper bioinorganic chemistry: R. Papadakis et al.Inorg. Chem201352(10), 5824-5830 ; O. Schicke et al. Eur. J. Inorg. Chem. 2015, 3512–3518 ; J. A. Isaac et al. Inorg. Chem. 201655, 8263-8266 ; M.-C. Kafentzi et al. Dalton trans. 201645, 15994-16000 ; A. L. Concia et al. Inorg. Chem. 2017, 1023-1026 ; A. Kochem et al. ChemPlusChem 201782, 615-624 ; F. Gennarini et al. Inorg. Chem. 201756(14), 7704-7719 ; F. Gennarini et al. Inorg. Chim. Acta 2018,481, 113-119 ; M.-C. Kafentzi et al. Chem. Eur. J. 201824, 5213-5224 ; J. A. Isaac et al. Dalton trans. 201847, 9665-9676 ; A. Thibon-Pourret et al. Inorg. Chem. 201857, 12364−12375 ; A. Kochem et al. Eur. J. Inorg. Chem. 2018, 5039–5046 and A. L. Concia et al. In “Series in Chemistry, Energy and Environment”, Eds.K. Kadish and R. Guilard, World Scientific. Vol. 5: “Bioinspired Chemistry: From Enzymes to Synthetic Models.”, Ed.M. Réglier, 2019, pp. 185-263.

B) [NiFe]hydrogenase (in collaboration with M. Orio, B. Faure and R. Hardré)
Biomimetic chemistry focused on functional models to perform the reversible transformation of protons to H2.

Publications: T. Straistari et al. ChemCatChem 20179, 2262-2268, Eur. J. Inorg. Chem. 2018, 2259-2266 and Chem. Eur. J. 201824, 8779-8786.

C) Molybdenum-containing enzymes (in collaboration with O. Iranzo, M. Orio and R. Hardré) 
Biomimetic chemistry focused on functional models of Formate dehydrogenases (Fdh) that perform the reversible transformation of COinto formate.

Publication: E. Oheix et al. Eur. J. Inorg. Chem. 2018, 1427-1434.

 

Collaborations et groupes

French Collaborations

Drs. Yves Le Mest and Nicolas Le Poul, CEMCA UMR CNRS 6521, Université de Bretagne Occidentale
Drs. Aurore Thibon Pourret, Hélène Jamet and Catherine Belle, DCM UMR CNRS 5250, Université Grenoble Alpes
Dr. Vincent Artero, LCBM UMR CNRS/CEA 5249, Université Grenoble Alpes
Pr. Bruno Guigliareli, BIP UMR CNRS 7281, Aix Marseille Université

Dr. Jean Guy Berrin, BBF UMR INRA, Aix Marseille Université

International Collaborations

Pr. Franc Meyer, Institut für Anorganische Chemie, Georg-August-Universität Göttingen (Germany)
Pr. Luigi Bubacco, Department of Biology, University of Padova (Italy)
Pr. Surajit Sinha, Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata (India)

 

Responsabilités administratives

2016-: Scientific Committee Member of the CEEBIOS (Centre Européen d'Excellence en Biomimetisme de Senlis)

2017-: Scientific Committee Member of the COSMETHICS, Cosmethics at the confluence of beauty and health (CDP 2017, Cross Disciplinary Program of Université Grenoble Alpes)

Actions de vulgarisation

2016-… Member of the association "Les Apprentis Chercheurs" that allows high school students to develop a research project in an research laboratory.

  • 2016-2017 Skin whitening, a dangerous case of the tyrosinase inhibition
  • 2017-2018 Bacteria and antibacterials
  • 2018-2019 Fruit browning, ethylene and polyphenol oxidases
  • 2019-2020 Copper complexes and cancers

2018-… Mentoring in the association "Les Savanturiers" that mobilizes and federates schools (primary and high schools) and the scientific communities (Universities, CNRS …) to promote sciences in an educational program.

  • 2018-2019 Around earthworms in the ecosystems, with the primary school Rabelais in Creil (Oise).
Publications (79)
RéférenceRésumé graphique
Oxidative C—H and C—C Bond Cleavage by a (2,2′-Bipyridine)Copper(I) Chloride Complex

Róbert Csonka, József Kaizer, Michel Giorgi, M. Réglier, László Hajba, János Mink, Gábor Speier, Inorganic Chemistry, 2008, 47, 6121-6123. <hal-01948938>
Manganese and iron flavonolates as flavonol 2,4-dioxygenase mimics

József Kaizer, Gábor Baráth, József Pap, Gábor Speier, Michel Giorgi, M. Réglier, Chemical Communications, 2007, 5235. <hal-01948930>
New insights in the mechanism of the dioxygen activation catalyzed by the Dopamine beta-monoxygenase.

P. Slama, M. Reglier(2007) C. R. Chimie 10, 731-741.
Characterization of Cu(II)-ACC Complexes and Conversion of the Bound ACC into Ethylene in the Presence of Hydrogen Peroxide. Detection of a Brown Intermediate at Low Temperature

Wadih Ghattas, Michel Giorgi, Christian Gaudin, Antal Rockenbauer, Marius Réglier, A. Jalila Simaan, Bioinorganic Chemistry and Applications, 2007, 2007, 43424. <hal-02299044>
Synthesis, structure and catalase mimics of novel homoleptic manganese(II) complexes of 1,3-bis(2′-pyridylimino)isoindoline, Mn(4R-ind)2 (R=H, Me)

József Kaizer, Gábor Baráth, Gábor Speier, M. Réglier, Michel Giorgi, Inorganic Chemistry Communications, 2007, 10, 292-294. <hal-01948935>
Cerium(IV)-mediated oxidation of flavonol with relevance to flavonol 2,4-dioxygenase. Direct evidence for spin delocalization in the flavonoxy radical

József Kaizer, Ildikó Ganszky, Gábor Speier, Antal Rockenbauer, László Korecz, Michel Giorgi, M. Réglier, Serge Antonczak, Journal of Inorganic Biochemistry, 2007, 101, 893-899. <hal-01948933>
New Functional Model Complexes of Intradiol-Cleaving Catechol Dioxygenases: Properties and Reactivity of Cu(II)(L)(O2Ncat).

J. Kaizer, Z. Zsigmond, I. Ganszky, G. Speier, M. Giorgi, M. Reglier(2007) Inorg. Chem. 46, 4660-4666.
Synthesis, structure and catalase-like activity of Cu(N-baa)2(phen) (phen = 1,10-phenanthroline, N-baaH = N-benzoylanthranilic acid).

J. Kaizer, T. Csay, G. Speier, M. Reglier and M. Giorgi. Inorg. Chem. Comm. 2006, 9, 1037-1039.
Preparation and X-ray Structure of a Catecholato Copper(II) Complex with a Schönberg Adduct.

B. Tapodi, G. Speier, M. Giorgi, M. Reglier, T. Funabiki, L. Korecz, A. Rockenbauer. Inorg. Chem. Comm. 2006, 9, 367-370.
{Chloro-[N-benzyl-bis-(2-pyridyl-methyl)amino]-copper(II)} perchlorate,[Cu(bnbpa)Cl]ClO4.

J. Kaizer, S. Góger, G. Speier, M. Giorgi, M. Reglier. Z. Kristallogr. NCS, 2006, 221, 75-76.

Pages

Chapitres d'ouvrages (2)
RéférenceRésumé graphique
A. Jalila Simaan, Alda Lisa Concia, Alessia Munzone, Maria-Chrysanthi Kafentzi, Amélie Kochem, et al.. Modeling the Mononuclear Copper Monooxygenase Active Site. Series on Chemistry, Energy and the Environment: Volume 5 Bioinspired Chemistry; From Enzymes to Synthetic Models, pp.185-263, 2019, ⟨10.1142/9789813274440_0008⟩. ⟨hal-02094996⟩
A. Jalila Simaan, Marius Réglier. CHAPTER 20. 1-Aminocyclopropane-1-Carboxylic Acid Oxidase. 2-oxoglutarate-dependent oxygenases RSC Metallobiology Series, 3., pp.425-437, 2015, ⟨10.1039/9781782621959-00425⟩. ⟨hal-02095042⟩