Dr. Olga IRANZO
Dr.
Olga
IRANZO
AMU iSm2 Service 341
Campus Scientifique de St Jérôme
13397
Marseille cedex 20
Téléphone :
Fax :
0491 28 8440
Courriel :
Parcours :
Education
- Habilitation à Diriger des Recherches, Aix-Marseille Université, Marseille, France, 2017
- Ph.D., Chemistry,University at Buffalo - SUNY, Buffalo, New York, USA, 2003
- M.S., Biotechnology, University of Barcelona, Barcelona, Spain, 1997
- B.S., Chemistry (Biochemistry), University Autónoma of Barcelona, Bellaterra, Spain, 1995
- B.S., Chemistry (Organic Chemistry), University of Barcelona, Barcelona, Spain, 1990
Experience
- 2021 – present, DR2 CNRS, Institut des Sciences Moléculaires de Marseille, BiosCiences, CNRS UMR 7313, Marseille, France
- 2013 – 2020, CRCN CNRS, Institut des Sciences Moléculaires de Marseille, BiosCiences, CNRS UMR 7313, Marseille, France
- 5/2008 – 2012, Group Leader, Head of the Laboratory of Bioinorganic Chemistry and Peptide Design, Instituto de Tecnologia Química e Biológica (ITQB) - Universidade Nova de Lisboa, Oeiras, Portugal
- 2004 – 4/2008, Postdoctoral research, Chemistry Department, University of Michigan, Ann Arbor, Michigan, USA
- 1995 – 1997, Research Scientist, R&D Department, Rhône-Poulenc, S.A, Barcelona, Spain
- 1992 – 1995, Laboratory Assistant (1992-1993)/ Manager (1993-1995), Development Department, Acabados Navas - KELAN, S.A, Barcelona, Spain
Distinctions :
- Silbert Award Recipient Fall 2000-Spring 2001. University at Buffalo – SUNY.
- The Mark Diamond Research Fund Award 2002. University at Buffalo – SUNY.
- Margaret and Herman Sokol Postdoctoral Award Recipient 2005. University of Michigan.
- American Heart Association Postdoctoral Fellowship 7/2006-4/2008, University of Michigan.
- Santander-Totta/UNL Scientific Award 2010 (shared with Prof. Ana Cecília A. Roque). Project: “Peptidomimetics on Magnetics Beads for Bioseparation Processes”.
Enseignements :
- 2013-2020, Lecturer, Aix-Marseille Université, Campus Scientifique de Saint Jérôme, Master of Chemistry (M2R COCV): Synthetic Biology.
- 2017, Lecturer, FEBS combined practical and lecture course “Chemistry of metals in biological systems”, 21 – 28 May 2017, Louvain-la-Neuve, Belgium.
- 2009-2012, Lecturer ITQB - Universidade Nova de Lisboa, Lisbon, Portugal.
- Ph.D. program in “Biological and Chemical Sciences and Engineering”:Chemical peptide synthesis, Trends in catalysis, Peptides and peptidomimetics.
- 2006-2007, Lecturer, University of Michigan, Ann Arbor, Michigan, USA.
- Advance Inorganic Chemistry CHE 402.
- 2000, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Advance Inorganic Chemistry Laboratory CHE 322.
- 1998, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Organic Chemistry Laboratory CHE 202.
- 1990-1991, High School Teacher, Private School, Barcelona, Spain.
Thématiques :
Our research projects fold in the area of bioinorganic chemistry at the interface between biology, catalysis and medicinal chemistry. We are particularly interested in understanding how native systems work, in particular metalloenzymes, and using this knowledge to develop bioinspired functional systems with applications in the field of catalysis and therapy. In our approach we use peptides and peptidomimetics to harness chemical diversity with biological structural complexity and develop scaffolds with high affinity and specificity for different metal ions and targets of interest.
- De Novo designed metallo-peptides to understand biological relevant metal sites:
- - Mn/Fe/Cu-Superoxidase Dismutases
- - Zn-peptidases
- - Formate dehydrogenases
- Pepzymes: developing bioinspired functional systems for environmentally friendly chemical transformations and therapy
Collaborations et groupes :
French collaborations
- Pr. Bruno Guigliarelli, Dr. Anabella Ivancich and Dr. Vincent Fourmond, BIP UMR 7281 CNRS – AMU, Marseille
- Pr. Oliver Ouari, ICR UMR 7273 CNRS – AMU, Marseille
- Dr. Christelle Hureau, Laboratoire de Chimie de Coordination du CNRS UPR 8241, Toulouse
- Dr. Catherine Berthomieu, LIPM UMR 7265 CEA – CNRS – AMU, Cadarache
International collaborations
- Pr. Ana A. C. Roque, UCIBIO, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal
- Pr. Rita Delgado, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
- Dr. Ana Luisa Simplicio, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
- Pr. MD. Fabian Kiessling and Dr. Twan Lammers, Experimental Molecular Imaging, University of Aachen (RWTH), Germany
- Pr. Daniela Valensin, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy
- Pr. Oscar Palacios and Prof. Mercè Capdevila, Chemistry Department, Universitat Autònoma de Barcelona, Spain
- Pr. Mariona Sudope and Prof. Luis Rodríguez-Santiago, Chemistry Department, Universitat Autònoma de Barcelona, Spain
- Pr. Surajit Sinha, Indian Association for Cultivation of Science, Kolkata, India
- Pr. Silke Leimkühler, Institute of Biochemistry and Biology, Department of Molecular Enzymology, University of Potsdam, Germany
- Prof. Cristina Satriano, Department of Chemical Sciences, University of Catania, Italy
- Dr. Patrick Gamez and Dr. Ana Caballero, University of Barcelona, Spain
Responsabilités administratives :
- Member of The Mark Diamond Research Fund Council in 2002
- Member of the Scientific Committee of ITQB – UNL representing the Chemistry Division (2009-2013)
- Elected member of the iSm2 Laboratory Council (Conseil du Laboratoire) (2018-2023)
- Member of Management Committee of the COST Actions CM0803 (2010-2013) and CA18202 (2020-2023)
- Member of the organizing committees of ISABC-11(2011, Spain), CuBICS (2018, France), QBIC-V (2019, France), Thematic School METBIO2 (2019, France), JCC-SCF (2020, France)
- Chair of the Thematic School PEPPERSchool - Peptide and Protein Engineering: from Concepts to Biotechnological Applications ( First edition 2018, Carry-le-Rouet, France; Second edition 2021, Virtual )
Publications (23)
Reference
Résumé graphique
HAL
Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy
Quim Peña, Sergi Rodríguez-Calado, A. Jalila Simaan, Mercè Capdevila, Pau Bayón, Oscar Palacios, Julia Lorenzo, Olga Iranzo, Frontiers in Pharmacology, 2022, 13. <hal-03881444>
✓
Synthesis of Protected 3,4- and 2,3-Dimercaptophenylalanines as Building Blocks for Fmoc -Peptide Synthesis and Incorporation of the 3,4-Analogue in a Decapeptide Using Solid-Phase Synthesis
Isita Banerjee, Keshab Ch Ghosh, Emmanuel Oheix, Marion Jean, Jean-Valère Naubron, Marius Réglier, Olga Iranzo, Surajit Sinha, Journal of Organic Chemistry, 2021, 86, 2210-2223. <hal-03359178>
✓
The pH-Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial alpha-Helical Metalloprotein
Karl J Koebke, Toni Kühl, Elisabeth Lojou, Borries Demeler, Barbara Schoepp-Cothenet, Olga Iranzo, Vincent L Pecoraro, Anabella Ivancich, Angewandte Chemie International Edition, 2021, 60, 3974-3978. <hal-03017501>
✓
Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps
Charlène Esmieu, Raúl Balderrama-Martínez-Sotomayor, Amandine Conte-Daban, Olga Iranzo, Christelle Hureau, Inorganic Chemistry, 2021, 60, 1248-1256. <hal-03203129>
✓
Copper(II) N,N,O-chelating complexes as potential anticancer agents
Quim Peña, Giuseppe Sciortino, Jean-Didier Maréchal, Sylvain Bertaina, A. Jalila Simaan, Julia Lorenzo, Mercè Capdevila, Pau Bayón, Olga Iranzo, Òscar Palacios, Inorganic Chemistry, 2021, 60. <hal-03157314>
✓
The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties
Clarisse Roblin, Steve Chiumento, Olivier Bornet, Matthieu Nouailler, Christina S. Müller, Katy Jeannot, Christian Basset, Sylvie Kieffer-Jaquinod, Yohann Couté, Stéphane Torelli, Laurent Le pape, Volker Schünemann, Hamza Olleik, Bruno de La Villeon, Philippe Sockeel, Eric Di Pasquale, Cendrine Nicoletti, Nicolas Vidal, Leonora Poljak, Olga Iranzo, Thierry Giardina, Michel Fons, Estelle Devillard, Patrice Polard, Marc Maresca, Josette Perrier, Mohamed Atta, Francoise Guerlesquin, Mickaël Lafond, Victor Duarte, Proceedings of the National Academy of Sciences of the United States of America, 2020, 120, e2302405120. <hal-02920462>
✓
Rational De Novo Design of a Cu-Metalloenzyme for Superoxide Dismutation
Emilie Mathieu, Audrey Tolbert, Karl Koebke, Cédric Tard, Olga Iranzo, James Penner‐hahn, Clotilde Policar, Vincent Pecoraro, Chemistry - A European Journal, 2020, 26, 249-258. <hal-02402535>
✓
Peptidic Scaffolds To Reduce the Interaction of Cu(II) Ions with β-Amyloid Protein
Ana Caballero, Olga Iranzo, Alexandre Hautier, Raimon Sabaté, Patrick Gamez, Inorganic Chemistry, 2019, 59, 837-846. <hal-03030920>
✓
Studying the reactivity of “old” Cu(II) complexes for “novel” anticancer purposes
Quim Peña, Julia Lorenzo, Giuseppe Sciortino, Sergi Rodríguez-Calado, Jean-Didier Maréchal, Pau Bayón, A. Jalila Simaan, Olga Iranzo, Merce Capdevila, Oscar Palacios, Journal of Inorganic Biochemistry, 2019, 195, 51-60. <hal-02106686>
✖
The role of methylation in the copper( ii ) coordination properties of a His-containing decapeptide
Alexandre Hautier, Tiago Carvalho, Daniela Valensin, A. Jalila Simaan, Bruno Faure, Pedro Mateus, Rita Delgado, Olga Iranzo, Dalton Transactions, 2019, 48, 1859-1870. <hal-02106690>
✖
Pages
Dr.
Olga
IRANZO
Dr.
Olga
IRANZO
AMU iSm2 Service 341
Campus Scientifique de St Jérôme
13397
Marseille cedex 20
Téléphone :
Fax :
0491 28 8440
Courriel :
Parcours :
Education
- Habilitation à Diriger des Recherches, Aix-Marseille Université, Marseille, France, 2017
- Ph.D., Chemistry,University at Buffalo - SUNY, Buffalo, New York, USA, 2003
- M.S., Biotechnology, University of Barcelona, Barcelona, Spain, 1997
- B.S., Chemistry (Biochemistry), University Autónoma of Barcelona, Bellaterra, Spain, 1995
- B.S., Chemistry (Organic Chemistry), University of Barcelona, Barcelona, Spain, 1990
Experience
- 2021 – present, DR2 CNRS, Institut des Sciences Moléculaires de Marseille, BiosCiences, CNRS UMR 7313, Marseille, France
- 2013 – 2020, CRCN CNRS, Institut des Sciences Moléculaires de Marseille, BiosCiences, CNRS UMR 7313, Marseille, France
- 5/2008 – 2012, Group Leader, Head of the Laboratory of Bioinorganic Chemistry and Peptide Design, Instituto de Tecnologia Química e Biológica (ITQB) - Universidade Nova de Lisboa, Oeiras, Portugal
- 2004 – 4/2008, Postdoctoral research, Chemistry Department, University of Michigan, Ann Arbor, Michigan, USA
- 1995 – 1997, Research Scientist, R&D Department, Rhône-Poulenc, S.A, Barcelona, Spain
- 1992 – 1995, Laboratory Assistant (1992-1993)/ Manager (1993-1995), Development Department, Acabados Navas - KELAN, S.A, Barcelona, Spain
Distinctions :
- Silbert Award Recipient Fall 2000-Spring 2001. University at Buffalo – SUNY.
- The Mark Diamond Research Fund Award 2002. University at Buffalo – SUNY.
- Margaret and Herman Sokol Postdoctoral Award Recipient 2005. University of Michigan.
- American Heart Association Postdoctoral Fellowship 7/2006-4/2008, University of Michigan.
- Santander-Totta/UNL Scientific Award 2010 (shared with Prof. Ana Cecília A. Roque). Project: “Peptidomimetics on Magnetics Beads for Bioseparation Processes”.
Enseignements :
- 2013-2020, Lecturer, Aix-Marseille Université, Campus Scientifique de Saint Jérôme, Master of Chemistry (M2R COCV): Synthetic Biology.
- 2017, Lecturer, FEBS combined practical and lecture course “Chemistry of metals in biological systems”, 21 – 28 May 2017, Louvain-la-Neuve, Belgium.
- 2009-2012, Lecturer ITQB - Universidade Nova de Lisboa, Lisbon, Portugal.
- Ph.D. program in “Biological and Chemical Sciences and Engineering”:Chemical peptide synthesis, Trends in catalysis, Peptides and peptidomimetics.
- 2006-2007, Lecturer, University of Michigan, Ann Arbor, Michigan, USA.
- Advance Inorganic Chemistry CHE 402.
- 2000, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Advance Inorganic Chemistry Laboratory CHE 322.
- 1998, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Organic Chemistry Laboratory CHE 202.
- 1990-1991, High School Teacher, Private School, Barcelona, Spain.
Thématiques :
Our research projects fold in the area of bioinorganic chemistry at the interface between biology, catalysis and medicinal chemistry. We are particularly interested in understanding how native systems work, in particular metalloenzymes, and using this knowledge to develop bioinspired functional systems with applications in the field of catalysis and therapy. In our approach we use peptides and peptidomimetics to harness chemical diversity with biological structural complexity and develop scaffolds with high affinity and specificity for different metal ions and targets of interest.
- De Novo designed metallo-peptides to understand biological relevant metal sites:
- - Mn/Fe/Cu-Superoxidase Dismutases
- - Zn-peptidases
- - Formate dehydrogenases
- Pepzymes: developing bioinspired functional systems for environmentally friendly chemical transformations and therapy
Collaborations et groupes :
French collaborations
- Pr. Bruno Guigliarelli, Dr. Anabella Ivancich and Dr. Vincent Fourmond, BIP UMR 7281 CNRS – AMU, Marseille
- Pr. Oliver Ouari, ICR UMR 7273 CNRS – AMU, Marseille
- Dr. Christelle Hureau, Laboratoire de Chimie de Coordination du CNRS UPR 8241, Toulouse
- Dr. Catherine Berthomieu, LIPM UMR 7265 CEA – CNRS – AMU, Cadarache
International collaborations
- Pr. Ana A. C. Roque, UCIBIO, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal
- Pr. Rita Delgado, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
- Dr. Ana Luisa Simplicio, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
- Pr. MD. Fabian Kiessling and Dr. Twan Lammers, Experimental Molecular Imaging, University of Aachen (RWTH), Germany
- Pr. Daniela Valensin, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy
- Pr. Oscar Palacios and Prof. Mercè Capdevila, Chemistry Department, Universitat Autònoma de Barcelona, Spain
- Pr. Mariona Sudope and Prof. Luis Rodríguez-Santiago, Chemistry Department, Universitat Autònoma de Barcelona, Spain
- Pr. Surajit Sinha, Indian Association for Cultivation of Science, Kolkata, India
- Pr. Silke Leimkühler, Institute of Biochemistry and Biology, Department of Molecular Enzymology, University of Potsdam, Germany
- Prof. Cristina Satriano, Department of Chemical Sciences, University of Catania, Italy
- Dr. Patrick Gamez and Dr. Ana Caballero, University of Barcelona, Spain
Responsabilités administratives :
- Member of The Mark Diamond Research Fund Council in 2002
- Member of the Scientific Committee of ITQB – UNL representing the Chemistry Division (2009-2013)
- Elected member of the iSm2 Laboratory Council (Conseil du Laboratoire) (2018-2023)
- Member of Management Committee of the COST Actions CM0803 (2010-2013) and CA18202 (2020-2023)
- Member of the organizing committees of ISABC-11(2011, Spain), CuBICS (2018, France), QBIC-V (2019, France), Thematic School METBIO2 (2019, France), JCC-SCF (2020, France)
- Chair of the Thematic School PEPPERSchool - Peptide and Protein Engineering: from Concepts to Biotechnological Applications ( First edition 2018, Carry-le-Rouet, France; Second edition 2021, Virtual )
Publications (23)
| Reference | Résumé graphique | HAL |
|---|---|---|
|
Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy |
|
✓ |
|
Synthesis of Protected 3,4- and 2,3-Dimercaptophenylalanines as Building Blocks for Fmoc -Peptide Synthesis and Incorporation of the 3,4-Analogue in a Decapeptide Using Solid-Phase Synthesis |
|
✓ |
|
The pH-Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial alpha-Helical Metalloprotein |
|
✓ |
|
Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps |
|
✓ |
|
Copper(II) N,N,O-chelating complexes as potential anticancer agents |
|
✓ |
|
The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties |
|
✓ |
|
Rational De Novo Design of a Cu-Metalloenzyme for Superoxide Dismutation |
|
✓ |
|
Peptidic Scaffolds To Reduce the Interaction of Cu(II) Ions with β-Amyloid Protein |
|
✓ |
|
Studying the reactivity of “old” Cu(II) complexes for “novel” anticancer purposes |
|
✖ |
|
The role of methylation in the copper( ii ) coordination properties of a His-containing decapeptide |
|
✖ |