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Dr.
 
Marius
 
REGLIER

Portrait de Dr. Marius Reglier
Dr.
Marius
REGLIER
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
13397
Marseille cedex 20


Téléphone
Fax
0491 28 84 40

Parcours

Education:
1975: Master in Sciences, Paul Cézanne Univ. Aix-Marseille III
1976: Chemical Ingeneer, Ecole Supérieure de Chimie de Marseille
1980: First Ph. D., Paul Cézanne Univ. Aix-Marseille III, September 26, 1980, Reactivity of non-conjugated dienes towards the catalytic system PdCl2/CuCl2: cyclisation and allylic oxidations (Pr. B. Waegell and Dr. A. Heumann)
1984: Second Ph. D. (thèse d’Etat), Pierre and Marie Curie Univ. Paris VI, December 18, 1984, Syntheses and Reactivity of Thia and 1-Aza-3-Cyclohexenes (Dr. S. Julia)

Experience:
1980-1984: CNRS Researcher (Attaché de Recherche), Ecole Normale Supérieure, Pierre and Marie Curie Univ. Paris VI, Dr. S. Julia
1985-1986: Research Fellow; University of Geneva, Switzerland, Pr. W. Oppolzer.
1986-1994: CNRS Researcher (CR1), Paul Cézanne Univ. Aix-Marseille III, Pr. B. Waegell
1989-1990: Research Fellow, Lab. of Cellular and Molecular Neurobiology, Gif/Yvette, Dr. J. Mallet.
1992: Visiting scientist, Johns Hopkins Univ., Baltimore, USA, Pr. K. D. Karlin.
1994-2018 : CNRS Researcher (DR2 then DR1), Aix-Marseille Université
2018-: CNRS Research Director emeritus (DREM)

Past administrative positions:
1996-2004: Member of the organising committee of REncontres de Chimie Organique Biologique (President for RECOB8, 2000)
2000-2004: Appointed member of the CNRS Comité National section 20
2001-2006: President of the GIS CNRS/Univ. Paul Cézanne Club CNRS Métalloprotéines et Modèles

2006-2011: Member of the scientific committee of the Indo-French Center for the Promotion of the Advanced Research (CEFIPRA/IFCPAR)
2006-2008: Creaction and Head of the FRE CNRS 3005 BiosCiences

2007-2009: Member of the scientific committee of the ANR program blanc
2009-2012: Vice-president of the ANR program Retour Post-doctorant
2009-2017: Head of the team BiosCiences
 (iSm2 UMR CNRS 7313)
2010-2015: French member of the Management Committee Action COST CM1003, Biological Oxidation Reactions, Mechanisms and Design of new Catalysts
2012-2018: Scientific officier at the Institut de Chimie du CNRS

Distinctions

2002: Docteur et de Madame Henri Labbé prize from the French Academy of Science.
2002: JSPS fellowship

2004: France Berkeley Fund with J. P. Klinman, Department of Chemistry UC Berkeley
2011: CNRS Excellence in Science
2014Chaire d’excellence from FAPESP (São Paulo Research Fondation) in University of São Paulo (USP).

Enseignements

Aix Marseille Université
- Synthetic biology, M2 degree course in Master Chemistry

Université Paris Descartes
- Redox bio-inorganic chemistry, M2 degree course in Master Frontiers in Chemistry

Ecole de l’INSERM Liliane Bettencourt, double degree course Medecine/Science
- Chemical aspects of Epigenetic, L2 course for medical students
- Chemistry of the S-Adenosyl Methionine cofactor (MOOC)

Thématiques

Activation of small molecules (O2, H2, H2O, CO2 …) by metalloenzymes and their biomimetic/bioinspired models.

A) Cu-containing monooxygenases (in collaboration with J. A. Simaan, M. Orio, B. Faure, R. Hardré and C. Decroos) 
Focused on Tyrosinase (Ty), Dopamine beta-Hydroxylase (DbH), Peptidylglycine alpha-Amidating Monooxygenase (PAM), particulate Methane MonoOxygenase (pMMO) and Lytic Polysaccharide MonoOxygenase (LPMO):

- Functional and structural metalloenzyme models
- Mechanism-based inhibitors of DbH, PAM and Ty
- Purification and genetic expression of copper-containing monooxygenases.

B) [NiFe]hydrogenase (in collaboration with M. Orio, B. Faure and R. Hardré)
Biomimetic chemistry focused on functional models to perform the reversible transformation of protons to H2.

C) Molybdenum-containing enzymes (in collaboration with O. Iranzo, M. Orio and R. Hardré) 
Biomimetic chemistry focused on functional models of Formate dehydrogenases (Fdh) that perform the reversible transformation of COinto formate.

 

Collaborations et groupes

French Collaborations

Drs. Yves Le Mest and Nicolas Le Poul, CEMCA UMR CNRS 6521, Université de Bretagne Occidentale
Drs. Aurore Thibon Pourret and Catherine Belle, DCM UMR CNRS 5250, Université Grenoble Alpes
Dr. Vincent Artero, LCBM UMR CNRS/CEA 5249, Université Grenoble Alpes
Pr. Bruno Guigliareli, BIP UMR CNRS 7281, Aix Marseille Université

Dr. Jean Guy Berrin, BBF UMR INRA, Aix Marseille Université

International Collaborations

Pr. Franc Meyer, Institut für Anorganische Chemie, Georg-August-Universität Göttingen (Germany)
Pr. Luigi Bubacco, Department of Biology, University of Padova (Italy)
Pr. Surajit Sinha, Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata (India)

 

Responsabilités administratives

2016-: Scientific Committee Member of the CEEBIOS (Centre Européen d'Excellence en Biomimetisme de Senlis)

Publications (75)
RéférenceRésumé graphique
Tetranuclear and dinuclear phenoxido bridged copper complexes based on unsymmetrical thiosemicarbazone ligands

J. Isaac, A.-T. Mansour, R. David, A. Kochem, C. Philouze, S. Demeshko, F. Meyer, M. Réglier, J. Simaan, S. Caldarelli, M. Yemloul, H. Jamet, A. Thibon-Pourret, C. Belle, Dalton Transactions, 2018, 47, 9665-9676. <hal-01948728>
Effect of Monoelectronic Oxidation of an Unsymmetrical Phenoxido-Hydroxido Bridged Dicopper(II) Complex

Aurore Thibon-Pourret, Federica Gennarini, David Rolf, James Isaac, Isidoro López, Gisèle Gellon, Florian Molton, Laurianne Wojcik, Christian Philouze, David Flot, Yves Le Mest, Marius Réglier, Nicolas Le Poul, Hélène Jamet, Catherine Belle, Inorganic Chemistry, 2018, 57, 12364 - 12375. <hal-01884830>
Electrochemical Water Oxidation and Stereoselective Oxygen Atom Transfer Mediated by a Copper Complex

Maria-Chrysanthi Kafentzi, Raffaello Papadakis, Federica Gennarini, Amélie Kochem, Olga Iranzo, Yves Le Mest, Nicolas Le Poul, Thierry Tron, Bruno Faure, A. Jalila Simaan, Marius Réglier, Chemistry - A European Journal, 2018. <hal-01711795>
An Air-Stable Molybdenum-Based Precatalyst in Oxygen-Atom Transfer Reactions

Emmanuel Oheix, Maylis Orio, Michel Giorgi, M. Réglier, Olga Iranzo, Renaud Hardré, European Journal of Inorganic Chemistry, 2018, 2018, 1427-1434. <hal-01948731>
Effect of ligand exchange on the one-electron oxidation process of alkoxo or phenoxo bridged binuclear copper(II) complexes

Federica Gennarini, Amélie Kochem, James Isaac, Ali-Taher Mansour, Isidoro López, Yves Le Mest, Aurore Thibon-Pourret, Bruno Faure, Hélène Jamet, Nicolas Le Poul, Catherine Belle, A. Jalila Simaan, M. Réglier, Inorganica Chimica Acta Reviews, 2018, 481, 113-119. <hal-01948733>
Influence of the Metal Ion on the Electrocatalytic Hydrogen Production by a Thiosemicarbazone Palladium Complex

Tatiana Straistari, Renaud Hardré, Julien Massin, Mireille Attolini, Bruno Faure, Michel Giorgi, M. Réglier, Maylis Orio, European Journal of Inorganic Chemistry, 2018, 2259-2266. <hal-01948729>
Hydrogen evolution reaction catalyzed by a bis(thiosemicarbazone) cobalt complex: An experimental and theoretical study.

Tatiana Straistari, Renaud Hardré, Jennifer Fize, Sergiu Shova, Michel Giorgi, Marius Réglier, Vincent Artero, Maylis Orio, Chemistry - A European Journal, 2018, 24, 8779 – 8786. <hal-01771020>
2-Hydroxypyridine- N -oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

Romain Haudecoeur, Marc Carotti, Aurélie Gouron, Marc Maresca, Elina Buitrago, Renaud Hardré, Elisabetta Bergantino, Hélène Jamet, Catherine Belle, Marius Réglier, Luigi Bubacco, Ahcène Boumendjel, ACS Medicinal Chemistry Letters, 2017, 8, 55 - 60. <hal-01617843>
Characterization of a Dinuclear Copper(II) Complex and Its Fleeting Mixed-Valent Copper(II)/Copper(III) Counterpart

Amélie Kochem, Federica Gennarini, Mehdi Yemloul, Maylis Orio, Nicolas Le Poul, Eric Rivière, Michel Giorgi, Bruno Faure, Yves Le Mest, Marius Réglier, A. Jalila Simaan, ChemPlusChem, 2017, 82, 615 - 624. <hal-01624533>
Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

Alda Lisa Concia, Maria Rosa Beccia, Maylis Orio, Francine Terra Ferre, Marciela Scarpellini, Frédéric Biaso, Bruno Guigliarelli, Marius Réglier, A. Jalila Simaan, Inorganic Chemistry, 2017, 56, 1023 - 1026. <hal-01440965>

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