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Dr. Marius Reglier's picture
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
Marseille cedex 20

0491 28 84 40


1975: Master in Sciences, Paul Cézanne Univ. Aix-Marseille III.
1976: Chemical Ingeneer, Ecole Supérieure de Chimie de Marseille.
1980: First Ph. D., Paul Cézanne Univ. Aix-Marseille III, September 26, 1980: Reactivity of non-conjugated dienes towards the catalytic system PdCl2/CuCl2: cyclisation and allylic oxidations (Pr. B. Waegell and Dr. A. Heumann).
1984: Second Ph. D. (thèse d’Etat), Pierre and Marie Curie Univ. Paris VI, December 18, 1984: Syntheses and Reactivity of Thia and 1-Aza-3-Cyclohexenes (Dr. S. Julia).

1980-1984: CNRS Researcher (CR2), Ecole Normale Supérieure, Pierre and Marie Curie Univ. Paris VI, Dr. S. Julia
1985-1986: Research Fellow; University of Geneva, Switzerland, Pr. W. Oppolzer.
1986-1994: CNRS Researcher (CR1), Paul Cézanne Univ. Aix-Marseille III, Pr. B. Waegell
1989-1990: Research Fellow, Lab. of Cellular and Molecular Neurobiology, Gif/Yvette, Dr. J. Mallet.
1992: Visiting scientist, Johns Hopkins Univ., Baltimore, USA, Pr. K. D. Karlin.
1994- : CNRS Researcher (DR2 then DR1), Paul Cézanne Univ. Aix-Marseille III.

2002: “Docteur et de Madame Henri Labbé” prize from the French Academy of Science.
2002: JSPS fellowship
2011: CNRS Excellence in Science


- “Electron Paramagnetic Resonance Spectroscopy”, Bachelor courses in Chemistry, Univ. of La Réunion.
- “Chemistry of living organisms”, Bachelor courses in Physical and Chemical Sciences, Paul Cézanne Univ. Aix-Marseille III.
- “Chemical tools for the study of biomolecules”, Master courses in Chemistry, Paul Cézanne Univ. Aix-Marseille III.
- “Metals and Nutrition”, Master courses in Nutrition and Food Safety, Paul Cézanne Univ. Aix-Marseille III.
- “Introduction to Inorganic Chemistry in Biology”, Ph. D. courses, Naples Federico II Univ., Italy.
- “Copper-containing monooxygenases and related enzymes”, Summer School in from chemistry to biology and médicine via metals, Heraklion Univ., Greece.


- Cu-containing monooxygenases: Tyrosinase (Ty), Dopamine -Hydroxylase (DH), Peptidylglycine -Amidating Monooxygenase (PAM), particulate Methane MonoOxygenase (pMMO).
- Biomimetic chemistry focused on functional and structural metalloenzyme models,
- Study of mechanism-based inhibitors of DH, PAM and Ty,
- Purification and genetic expression of copper-containing monooxygenases.

Responsabilités administratives

1996-2004: member of the organising committee of REncontres de Chimie Organique Biologique (President for RECOB8, 2000)
2000-2004: appointed member of the CNRS Comité National section 20
2001-2006: President of the GIS CNRS/Univ. Paul Cézanne « Club CNRS Métalloprotéines et Modèles

2006-2011: Member of the scientific committee of the Indo-French Center for the Promotion of the Advanced Research (CEFIPRA/IFCPAR)
2006-2008: Head of the FRE CNRS 3005 BiosCiences

2007-2009: member of the scientific committee of the ANR program “blanc”
2009-2012: Vice-president of the ANR program “Retour Post-doctorant”
2012-: Scientific officier at the Institut de Chimie du CNRS

Publications (58)
RéférenceRésumé graphique
Effect of ligand exchange on the one-electron oxidation process of alkoxo or phenoxo bridged binuclear copper(II) complexes

Federica Gennarini, Amélie Kochem, James Isaac, Ali-Taher Mansour, Isidoro López, Yves Le Mest, Aurore Thibon-Pourret, Bruno Faure, Hélène Jamet, Nicolas Le Poul, Catherine Belle, A. Jalila Simaan, Marius Réglier, Inorganica Chimica Acta Reviews, 2017, 56, 4266 - 4271. <hal-01639590>
Influence of Asymmetry on the Redox Properties of Phenoxo- and Hydroxo-Bridged Dicopper Complexes: Spectroelectrochemical and Theoretical Studies

Federica Gennarini, Rolf David, Isidoro López, Yves Le Mest, Marius Réglier, Catherine Belle, Aurore Thibon-Pourret, Hélène Jamet, Nicolas Le Poul, Inorganic Chemistry, 2017, 56, 7707 - 7719. <hal-01624535>
Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

Alda Lisa Concia, Maria Rosa Beccia, Maylis Orio, Francine Terra Ferre, Marciela Scarpellini, Frédéric Biaso, Bruno Guigliarelli, Marius Réglier, A. Jalila Simaan, Inorganic Chemistry, 2017, 56, 1023 - 1026. <hal-01440965>
2-Hydroxypyridine- N -oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

Romain Haudecoeur, Marc Carotti, Aurélie Gouron, Marc Maresca, Elina Buitrago, Renaud Hardré, Elisabetta Bergantino, Hélène Jamet, Catherine Belle, Marius Réglier, Luigi Bubacco, Ahcène Boumendjel, ACS Medicinal Chemistry Letters, 2017, 8, 55 - 60. <hal-01617843>
Characterization of Cu(II)-reconstituted ACC Oxidase using experimental and theoretical approaches

Nadia El Bakkali-Tahéri, Sybille Tachon, Maylis Orio, Sylvain Bertaina, Marlène Martinho, Viviane Robert, Marius Réglier, Thierry Tron, Pierre Dorlet, A. Jalila Simaan, Archives of Biochemistry and Biophysics, 2017, 623-624, 31 - 41. <hal-01627933>
Characterization of a Dinuclear Copper(II) Complex and Its Fleeting Mixed-Valent Copper(II)/Copper(III) Counterpart

Amélie Kochem, Federica Gennarini, Mehdi Yemloul, Maylis Orio, Nicolas Le Poul, Eric Rivière, Michel Giorgi, Bruno Faure, Yves Le Mest, Marius Réglier, A. Jalila Simaan, ChemPlusChem, 2017, 82, 615 - 624. <hal-01624533>
Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco, Marius Réglier, Current Topics in Medicinal Chemistry, 2016, 16, 3033 - 3047. <hal-01644550>
Changing the chemical and physical properties of high valent heterobimetallic bis-(μ-oxido) Cu–Ni complexes by ligand effects

Maria-Chrysanthi Kafentzi, Maylis Orio, Marius Réglier, Shenglai Yao, Uwe Kuhlmann, Peter Hildebrandt, Matthias Driess, A. Jalila Simaan, Kallol Ray, Dalton Transactions, 2016, 45, 15994 - 16000. <hal-01475476>
Formation, Characterization, and Reactivity of a Nonheme Oxoiron(IV) Complex Derived from the Chiral Pentadentate Ligand asN4Py

Dóra Lakk-Bogáth, Róbert Csonka, Gábor Speier, Marius Réglier, A. Jalila Simaan, Jean-Valère Naubron, Michel Giorgi, Károly Lázár, József Kaizer, Inorganic Chemistry, 2016, 55, 10090 - 10093. <hal-01475455>
Oxidative DNA Cleavage Promoted by a Phenoxyl-Radical Copper(II) Complex

Olesea Cuzan, Amélie Kochem, A. Jalila Simaan, Sylvain Bertaina, Bruno Faure, Viviane Robert, Sergiu Shova, Michel Giorgi, Michel Maffei, Marius Réglier, Maylis Orio, European Journal of Inorganic Chemistry, 2016, 2016, 5575 - 5584. <hal-01475484>