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Dr.
 
Olga
 
IRANZO

Portrait de Dr. Olga Iranzo
Dr.
Olga
IRANZO
AMU iSm2 Service 341
Campus Scientifique de St Jérôme
13397
Marseille cedex 20


Téléphone
Fax
0491 28 8440

Parcours

Education

  • Habilitation à Diriger des Recherches, Aix-Marseille Université, Marseille, France, 2017
  • Ph.D., Chemistry,University at Buffalo - SUNY, Buffalo, New York, USA, 2003
  • M.S., Biotechnology, University of Barcelona, Barcelona, Spain, 1997
  • B.S., Chemistry (Biochemistry), University Autónoma of Barcelona, Bellaterra, Spain, 1995
  • B.S., Chemistry (Organic Chemistry), University of Barcelona, Barcelona, Spain, 1990

Experience

  • 2013 – present, CRCN CNRS, Institut des Sciences Moléculaires de Marseille, BiosCiences, CNRS UMR 7313, Marseille, France
  • 5/2008 – 2012, Group Leader, Head of the Laboratory of Bioinorganic Chemistry and Peptide DesignInstituto de Tecnologia Química e Biológica (ITQB) - Universidade Nova de Lisboa, Oeiras, Portugal
  • 2004 – 4/2008, Postdoctoral research, Chemistry Department, University of Michigan, Ann Arbor, Michigan, USA
  • 1995 – 1997, Research Scientist, R&D Department, Rhône-Poulenc, S.A, Barcelona, Spain
  • 1992 – 1995, Laboratory Assistant (1992-1993)/ Manager (1993-1995), Development Department, Acabados Navas - KELAN, S.A, Barcelona, Spain
Distinctions
  • Silbert Award Recipient Fall 2000-Spring 2001. University at Buffalo – SUNY.
  • The Mark Diamond Research Fund Award 2002. University at Buffalo – SUNY.
  • Margaret and Herman Sokol Postdoctoral Award Recipient 2005. University of Michigan.
  • American Heart Association Postdoctoral Fellowship 7/2006-4/2008, University of Michigan.
  • Santander-Totta/UNL Scientific Award 2010 (shared with Prof. Ana Cecília A. Roque). Project: “Peptidomimetics on Magnetics Beads for Bioseparation Processes”.
Enseignements
  • 2013-2019, Lecturer, Aix-Marseille Université, Campus Scientifique de Saint Jérôme, Master of Chemistry (M2R COCV): Synthetic Biology.
  • 2017, Lecturer, FEBS combined practical and lecture course “Chemistry of metals in biological systems”, 21 – 28 May 2017, Louvain-la-Neuve, Belgium.
  • 2009-2012, Lecturer ITQB - Universidade Nova de Lisboa, Lisbon, Portugal.
  • Ph.D. program in “Biological and Chemical Sciences and Engineering”:Chemical peptide synthesis, Trends in catalysis, Peptides and peptidomimetics.
  • 2006-2007, Lecturer, University of Michigan, Ann Arbor, Michigan, USA.
  • Advance Inorganic Chemistry CHE 402.
  • 2000, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Advance Inorganic Chemistry Laboratory CHE 322.
  • 1998, Teaching Assistant, University at Buffalo – SUNY, Buffalo, New York, USA, Organic Chemistry Laboratory CHE 202.
  • 1990-1991, High School Teacher, Private School, Barcelona, Spain.
Thématiques

Our research projects fold in the area of bioinorganic chemistry at the interface between biology, catalysis and medicinal chemistry. We are particularly interested in understanding how native systems work, in particular metalloenzymes, and using this knowledge to develop new functional systems with applications in the field of catalysis and therapy. In our approach we use peptides and peptidomimetics to harness chemical diversity with biological structural complexity and develop scaffolds with high affinity and specificity for different metal ions and targets of interest.

  • De Novodesigned metallo-peptides to understand biological relevant metal sites:
  1. - Mn/Fe/Cu-Superoxidase Dismutases
  2. - Formate dehydrogenases
  • Pepzymes: developing catalysts for environmentally friendly chemical transformations and therapy
Collaborations et groupes

French collaborations

  • Pr. Bruno Guigliarelli, Dr. Anabella Ivancich and Dr. Vincent Fourmond, BIP UMR 7281 CNRS – AMU, Marseille
  • Dr. Paul Brémond, CRCM, AMU – INSERM U1068 – CNRS UMR 7258, Marseille
  • Dr. Christelle Hureau, Laboratoire de Chimie de Coordination du CNRS UPR 8241, Toulouse

International collaborations

  • Pr. Ana A. C. Roque, UCIBIO, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal
  • Pr. Rita Delgado, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
  • Dr. Ana Luisa Simplicio, Instituto de Tecnologia Química e Biológica – António Xavier, Universidade Nova de Lisboa, Portugal
  • Pr. MD. Fabian Kiessling and Dr. Twan Lammers, Experimental Molecular Imaging, University of Aachen (RWTH), Germany
  • Pr. Daniela Valensin, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy
  • Pr. Oscar Palacios and Prof. Mercè Capdevila, Chemistry Department, Universitat Autònoma de Barcelona, Spain
  • Pr. Mariona Sudope and Prof. Luis Rodríguez-Santiago, Chemistry Department, Universitat Autònoma de Barcelona, Spain
  • Pr. Surajit Sinha, Indian Association for Cultivation of Science, Kolkata, India
Responsabilités administratives
  • Member of The Mark Diamond Research Fund Council in 2002
  • Member of the Scientific Committee of ITQB – UNL representing the Chemistry Division (2009-2013)
  • Elected member of the iSm2 Laboratory Council (Conseil du Laboratoire) (2018-2023)
  • Member of Management Committee of the COST Action CM0803 (10/2010-2013)
  • Member of the organizing committees of “ISABC-11th” (2-5/12/ 2011, Spain), CuBICS (21-24/5/ 2018, France)
  • Chair of the Thematic School PEPPERSchool - Peptide and Protein Engineering: from Concepts to Biotechnological Applications (13-17/5/2018, Carry-le-Rouet, France)
Publications (9)
RéférenceRésumé graphique
Studying the reactivity of “old” Cu(II) complexes for “novel” anticancer purposes

Quim Peña, Julia Lorenzo, Giuseppe Sciortino, Sergi Rodríguez-Calado, Jean-Didier Maréchal, Pau Bayón, A. Jalila Simaan, Olga Iranzo, Merce Capdevila, Oscar Palacios, Journal of Inorganic Biochemistry, 2019, 195, 51-60. <hal-02106686>
The role of methylation in the copper( ii ) coordination properties of a His-containing decapeptide

Alexandre Hautier, Tiago Carvalho, Daniela Valensin, A. Jalila Simaan, Bruno Faure, Pedro Mateus, Rita Delgado, Olga Iranzo, Dalton Transactions, 2019, 48, 1859-1870. <hal-02106690>
Electrochemical Water Oxidation and Stereoselective Oxygen Atom Transfer Mediated by a Copper Complex

Maria-Chrysanthi Kafentzi, Raffaello Papadakis, Federica Gennarini, Amélie Kochem, Olga Iranzo, Yves Le Mest, Nicolas Le Poul, Thierry Tron, Bruno Faure, A. Jalila Simaan, Marius Réglier, Chemistry - A European Journal, 2018. <hal-01711795>
An Air-Stable Molybdenum-Based Precatalyst in Oxygen-Atom Transfer Reactions

Emmanuel Oheix, Maylis Orio, Michel Giorgi, M. Réglier, Olga Iranzo, Renaud Hardré, European Journal of Inorganic Chemistry, 2018, 2018, 1427-1434. <hal-01948731>
Characterization of plasma labile heme in hemolytic conditions

Zélia Gouveia, Ana Carlos, Xiaojing Yuan, Frederico Aires-Da-Silva, Roland Stocker, Ghassan Maghzal, Sónia Leal, Cláudio Gomes, Smilja Todorovic, Olga Iranzo, Susana Ramos, Ana Santos, Iqbal Hamza, Joao Goncalves, Miguel Soares, FEBS Journal, 2017, 284, 3278 - 3301. <hal-01793489>
Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons

Alexandra Gennaris, Benjamin Ezraty, Camille Henry, Rym Agrebi, Alexandra Vergnes, Emmanuel Oheix, Julia Bos, Pauline Leverrier, Leon Espinosa, Joanna Szewczyk, Didier Vertommen, Olga Iranzo, Jean-Francois Collet, Frederic Barras, Nature, 2015, 528, 409+. <hal-01452073>
Comparison of the Internal Dynamics of Metalloproteases Provides New Insights on Their Function and Evolution

Henrique F. Carvalho, Ana C. A. Roque, Olga Iranzo, Ricardo J. F. Branco, PLoS ONE, 2015, 10. <hal-01237625>
An Experimental and Theoretical Evaluation of Multi-site Cd(II) Exchange in Designed Three-Stranded Coiled Coil Peptides.

S. Chakraborty, O. Iranzo, E. R. P. Zuiderweg and V. L. Pecoraro. J. Am. Chem. Soc., 2012, 134, 6191–6203.
Controlling and Fine Tuning the Physical Properties of Two Identical Metal Coordination Sites in De Novo Designed Three Stranded Coiled Coil Peptides.

O. Iranzo, S. Chakraborty, L. Hemmingsen, V. L. Pecoraro. J. Am. Chem. Soc., 2011, 133, 239-251.