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Dr.
 
Xavier
 
BUGAUT

Portrait de Dr. Xavier Bugaut
Dr.
Xavier
BUGAUT
AMU iSm2 service 541
Campus Scientifique de St Jérôme
13397
Marseille cedex 20
FRANCE


Téléphone
Fax
0491 28 9187

Parcours

Since 2011: Maître de Conférences (equivalent to assistant professor), Aix Marseille Université, iSm2, team STEREO.

2010-2011: Postdoctoral research associate, Westfälische Wilhelms-Universität Münster, Germany, supervisor: Prof. Dr. Frank Glorius.

2006-2009: PhD in Organic Chemistry, Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette, France, supervisor: Dr. Emmanuel Roulland.

2006: Master degree training period, Sanofi-Aventis, Vitry-sur-Seine, supervisors: Dr. Arielle Genevois-Borella and Dr. Ingrid Devillers.

2005-2006: Master degree in Chemistry, Université Montpellier II. 2004-2005: One-year training period, Merck KGaA, Darmstadt, Allemagne, supervisor: Dr. Ulrich Emde.

2002-2006: Degree in chemical engineering, with specialization in fine organic chemistry, Ecole Nationale Supérieure de Chimie de Montpellier

Enseignements

Bachelor's degree in Chemistry:

4th semester: reaction mechanisms (coordinator)

 

Master's degree in Chemistry:

8th semester: pericyclic reactions and stereoelectronic effets

8th semester: experimental projects

9th semester: advanced organocatalysis

 

Selective and multidisciplinary Bachelor's degree co-habilitated by Ecole Centrale Marseille in Mathematics-Physics-Chemistry-Informatics (MPCI):

1st semester: introduction to organic chemistry (representation of molecules, nomenclature, stereochemistry)

3rd semester: reaction mechanisms

Thématiques

. Enantioselective Organocatalysis

- Synthesis and Use of Original 1,3-Dicarbonyl Compounds

- Enantioselective Multicomponent Reactions

- Halogen-Bonding Organocatalysis

- Synthesis of Axially Chiral Compounds by Central-to-Axial Conversion of Chirality

. Dearomatization of Aromatic compounds

. Total Synthesis of Natural Products

Collaborations et groupes

Current students:

- Arun Kumar Ramar (post-doctoral research associate)

- Clément Lemaître (2nd-year PhD student)

- Chunyang Li (2nd-year PhD student, in collaboration with Prof. Alexandre Martinez and Dr. Bastien Chatelet)

- David Givaudan (3rd-year PhD student)

- Dr. Mouhamadou Fofana (exchange PhD student, Prof. Ibrahima Ndiaye, Université Cheikh Anta Diop, Dakar, Senegal)

Former students:

- Andrea Mambrini (Erasmus student, Università degli Studi di Perugia, Italy)

- Dr. Karthik Devaraj (post-doctoral research associate, 2018-2019 // now post-doctoral research associate with Prof. Cathleen Crudden, Queen's University, Kingston, Canada)

- Dr. Nicolas Dalmasso (post-doctoral research associate, 2017-2018 // now research chemist at Charnwood Molecular, Loughborough, UK )

- Hizia Chérif (Master student // now PhD student, Institut de Chimie radicalaire, Aix-Marseille Université)

- Pablo Romo Valdés (exchange PhD student, Prof. Jairo Quiroga Puello, Universidad del Valle, Cali, Colombia)

- Antonio Puglisi (exchange PhD student within the Erasmus programm, 2017, Prof. Marco Bella, La Sapienza Universita, Rome, Italy)

- Dr. Tanguy Saget ( post-doctoral research associate, 2016-2017 // then post-doctoral research associate with Prof. Burkhard König, Universität Regensburg, Germany // now CNRS researcher at the Institut de Chimie des Substances Naturelles, Gif-sur-Yvette)

- Dr. Yohan Dudognon (PhD student, 2013-2016 // then post-doctoral research associate with Prof. Alois Fürstner, Max-Planck-Institut für Kohlenforschung, Mülheim-an-der-Ruhr, Germany // now chemist at Aroma Sense, Marseille)

- Dr. Ophélie Quinonero (PhD student, 2013-2016 // then post-doctoral research associate with Prof. Antonio Echavarren, ICIQ, Tarragona, Spain // now medicinal chemist at Oxeltis, Montpellier)

- Ronan Rocaboy (Master student, 2015 // then PhD student with Prof. Olivier Baudoin, University of Basel, Switzerland // non post-doctoral research associate with Prof. Matthias Wymann at University of Basel, Switzerland)

- Dr. Haiying Du (PhD student, 2011-2014 // now assistant professor at the School of Environment, Chengdu University of Technology, China)

- Juan Martin Lopez (Master student, 2013)

- Dr. Maria del Mar Sanchez Duque (post-doc, 2012 // now sustainable development project manager, Clinique Pasteur, Toulouse)

Remerciements

The following institutions and companies are acknowledged for their financial support to our research activities:

- Aix Marseille Université

- Centre National de la Recherche Scientifique (CNRS)

- Agence Nationale de la Recherche (ANR) : ANR-19-CE07-0029-01 (Bond-X-Bond)

- A*MIDEX (Aix Marseille Université's excellence initiative) : A-M-AAP-EI-17-150-170301-11.01-BUGAUT-SAT (CDD)

- Provence-Alpes-Côte d'Azur region : ERC Booster 2018 (InterconvCat)

- Chinese Scolarship Council

- Janssen Cilag

- Provepharm

Responsabilités administratives

. Selective and multidisciplinary Bachelor's degree co-habilitated by Ecole Centrale Marseille in Mathematics-Physics-Chemistry-Informatics (MPCI):

-co-coordinator of the Bachelor's degreee

-coordinator of chemistry teaching over the three year of the Bachelor degree

-coordination of all teaching during the second year

. Coordination of STeRéO-group seminars

Publications (25)
RéférenceRésumé graphiqueHAL
Organocatalytic Enantioselective Synthesis of Tetrahydropyridines

Yohan Dudognon, Jean Rodriguez, Thierry Constantieux, Xavier Bugaut, European Journal of Organic Chemistry, 2018, 2018, 2432-2442. <hal-01969953>
Weinreb β-Ketoamides in Enantioselective Organocatalysis: A Balance between Reactivity and Selectivity

Haiying Du, Yohan Dudognon, Jean Rodriguez, Thierry Constantieux, Xavier Bugaut, SYNLETT, 2018. <hal-01723120>
Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

Vivek Raut, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Thierry Constantieux, Cyril Bressy, Xavier Bugaut, Damien Bonne, Jean Rodriguez, Journal of the American Chemical Society, 2017, 139, 2140-2143. <hal-01533761>
Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

Haiying Du, Yohan Dudognon, M. del Mar Sanchez Duque, Sébastien Goudedranche, Damien Bonne, Jean Rodriguez, Xavier Bugaut, Thierry Constantieux, SYNTHESIS, 2016, 48, 3479-3503. <hal-01415048>
From Simple Cyclic 1,3-Ketoamides to Complex Spirolactams by Supported Heterogeneous Organocatalysis with PS-BEMP

Aouicha Benmaati, Hadjira Habib Zahmani, Salih Hacini, José Carlos Menéndez, Xavier Bugaut, Jean Rodriguez, Thierry Constantieux, SYNTHESIS, 2016, 48, 3217 - 3231. <hal-01415069>
Addition of silylated nucleophiles to α-oxoketenes

Yohan Dudognon, Marc Presset, Jean Rodriguez, Yoann Coquerel, Xavier Bugaut, Thierry Constantieux, Chemical Communications, 2016, 52, 3010-3013. <hal-01323402>
Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines

Ophélie Quinonero, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Damien Bonne, Thierry Constantieux, Cyril Bressy, Xavier Bugaut, Jean Rodriguez, Angewandte Chemie International Edition, 2016, 55. <hal-01323419>
Organocatalytic multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydro-pyridines: key substrate selection enabling regio-and stereoselectivities †

Yohan Dudognon, Haiying Du, Jean Rodriguez, Xavier Bugaut, Thierry Constantieux, Chemical Communications, 2015, 51, 1980-1982. <hal-01133610>
Michael Addition Initiated Substrate- or Catalyst-Controlled Chemodivergent Three-Component Construction of Fused and Bridged Polycyclic Heterocycles

Haiying Du, Jean Rodriguez, Xavier Bugaut, Thierry Constantieux, SYNTHESIS, 2015, 47, 2188-2198. <hal-01224292>
Origin of the Enantioselectivity in Organocatalytic Michael Additions of beta-Ketoamides to alpha,beta-Unsaturated Carbonyls: A Combined Experimental, Spectroscopic and Theoretical Study

Adrien Quintard, Diana Cheshmedzhieva, Maria del Mar Sanchez Duque, Anouk Gaudel-Siri, Jean-Valère Naubron, Yves Génisson, Jean-Christophe Plaquevent, Xavier Bugaut, Jean Rodriguez, Thierry Constantieux, Chemistry - A European Journal, 2015, 21, 778-790. <hal-01133609>

Pages

Chapitres d'ouvrages (5)
RéférenceRésumé graphiqueHAL
Adrien Quintard, Xavier Bugaut, Thierry Constantieux. L'éco-conception, un défi pour la recherche fondamentale . Yvette Lazzeri, Dominique Bonet Fernandez & Mariane Domeizel. Economie circulaire et territoires, Presses universitaires d'Aix-Marseille, pp.133-137, 2017, 979-10-320-0097-7. ⟨hal-01533756⟩
Xavier Bugaut, Thierry Constantieux, Yoann Coquerel, Jean Rodriguez. 1,3-Dicarbonyls in Multicomponent Reactions. J. Zhu, Q. Wang, M.-X. Wang. Multicomponent Reactions in Organic Synthesis, Wiley-VCH, Weinheim, pp.109-158, 2014, 978-3-527-33237-3. ⟨hal-01133604⟩
Xavier Bugaut. Benzoin and aza-benzoin. Gary A. Molander and Paul Knochel. Comprehensive Organic Synthesis, 2nd Edition, Elsevier, pp.424-470, 2014, ⟨10.1016/B978-0-08-097742-3.00118-X⟩. ⟨hal-01066271⟩
Benzoin and Aza-Benzoin

Xavier Bugaut, In: Gary A. Molander and Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd Edition, Vol 1, Oxford: Elsevier, 2014, pp.424-470.
1,3-Dicarbonyls in Multicomponent Reactions

X. Bugaut, T. Constantieux, Y. Coquerel, J. Rodriguez, In Multicomponent Reactions in Organic Synthesis, Eds.: J. Zhu, Q. Wang, M.-X. Wang, Wiley-VCH, Weinheim, 2014, Chap. 5, pp 109-158.