Back to top


Portrait de Dr. Marius Reglier
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
Marseille cedex 20
0491 28 84 40

1975: Master in Sciences, Paul Cézanne Univ. Aix-Marseille III
1976: Chemical Ingeneer, Ecole Supérieure de Chimie de Marseille
1980: First Ph. D., Paul Cézanne Univ. Aix-Marseille III, September 26, 1980, Reactivity of non-conjugated dienes towards the catalytic system PdCl2/CuCl2: cyclisation and allylic oxidations (Pr. B. Waegell and Dr. A. Heumann)
1984: Second Ph. D. (thèse d’Etat), Pierre and Marie Curie Univ. Paris VI, December 18, 1984, Syntheses and Reactivity of Thia and 1-Aza-3-Cyclohexenes (Dr. S. Julia)

1980-1984: CNRS Researcher (Attaché de Recherche), Ecole Normale Supérieure, Pierre and Marie Curie Univ. Paris VI, Dr. S. Julia
1985-1986: Research Fellow; University of Geneva, Switzerland, Pr. W. Oppolzer.
1986-1994: CNRS Researcher (CR1), Paul Cézanne Univ. Aix-Marseille III, Pr. B. Waegell
1989-1990: Research Fellow, Lab. of Cellular and Molecular Neurobiology, Gif/Yvette, Dr. J. Mallet.
1992: Visiting scientist, Johns Hopkins Univ., Baltimore, USA, Pr. K. D. Karlin.
1994-2018 : Senior scientist at CNRS (Directeur de Recherche), Aix-Marseille Université
2018-: CNRS Research Director emeritus (DREM)

Past administrative positions:
1996-2004: Member of the organising committee of REncontres de Chimie Organique Biologique (President for RECOB8, 2000)
2000-2004: Appointed member of the CNRS Comité National section 20
2001-2006: Founding President of the GIS CNRS/Univ. Paul Cézanne Club CNRS Métalloprotéines et Modèles

2006-2011: Member of the scientific committee of the Indo-French Center for the Promotion of the Advanced Research (CEFIPRA/IFCPAR)
2006-2008: Founding Director of the FRE CNRS 3005 BiosCiences

2007-2009: Member of the scientific committee of the ANR program blanc
2009-2012: Vice-president of the ANR program Retour Post-doctorant
2009-2017: Head of the team BiosCiences
 (iSm2 UMR CNRS 7313)
2010-2015: French member of the Management Committee Action COST CM1003, Biological Oxidation Reactions, Mechanisms and Design of new Catalysts
2012-2018: Scientific officier at the Institut de Chimie du CNRS


2002: Docteur et de Madame Henri Labbé prize from the French Academy of Science.
2002: JSPS fellowship

2004: France Berkeley Fund with J. P. Klinman, Department of Chemistry UC Berkeley
2011: CNRS Excellence in Science
2014Chaire d’excellence from FAPESP (São Paulo Research Fondation) in University of São Paulo (USP).


Aix Marseille Université
- Synthetic biology, M2 degree course in Master Chemistry

Université de Paris
- Redox bio-inorganic chemistry, M2 degree course in Master Frontiers in Chemistry

Università degli Studi di catania (Italy), october 2021
- Introduction of non-canonical amino acids in protein synthesis in Doctoral course degree

Ecole de l’INSERM Liliane Bettencourt, double degree course Medecine/Science
- Chemical aspects of Epigenetic, L2 course for medical students


- Chemistry of the S-Adenosyl Methionine cofactor (MOOC)

 The S-Adenosyl Methionine cofactor



Activation of small molecules (O2, H2, H2O, CO2 …) by metalloenzymes and their biomimetic/bioinspired models.

A) Cu-containing monooxygenases (in collaboration with J. A. Simaan, M. Orio, B. Faure, R. Hardré and C. Decroos) 
Focused on Tyrosinase (Ty), Dopamine beta-Hydroxylase (DbH), Peptidylglycine alpha-Amidating Monooxygenase (PAM), particulate Methane MonoOxygenase (pMMO) and Lytic Polysaccharide MonoOxygenase (LPMO):

- Functional and structural metalloenzyme models
- Mechanism-based inhibitors of DbH, PAM and Ty
- Purification and genetic expression of copper-containing monooxygenases.

Selected publications on Tyrosinase inhibitionInorg. Chem. 200948, 10874–10876 ; Eur. J. Chem. Med. 201146, 4330-4335 ; Chem. Eur. J. 201117, 13482–13494 ; ChemBioChem 201213, 559-565 ; Chem. Eur. J. 201319, 3655-3664 ; Chem. Commun. 201450, 308-3010 ; ChemBioChem 2014,15(9), 1325–1333 ; Inorg. Chem. 201453, 12848-12858 ; J. Agr. Food Chem. 201664, 2925-2931 ; Current Topics in Medicinal Chemistry 201616(27), 3033-3047 ; ACS Med. Chem. Lett. 2017, 8 (1), 55-60 ; ChemEur J. 202127, 4384-4393..

Selected publications on LPMOInorg. Chem. 2017, 56, 1023-1026 ; FEBS J. 2020287, 3298–33143.

Selected publications on copper bioinorganic chemistryInorg. Chem201352(10), 5824-5830 ; Eur. J. Inorg. Chem. 2015, 3512–3518 ; Inorg. Chem. 201655, 8263-8266 ; Dalton trans. 201645, 15994-16000 ; ChemPlusChem 201782, 615-624 ; Inorg. Chem. 201756, 7704-7719 ; Inorg. Chim. Acta 2018,481, 113-119 ; Chem. Eur. J. 201824, 5213-5224 ; Dalton trans. 201847, 9665-9676 ; Inorg. Chem. 201857, 12364−12375 ; Eur. J. Inorg. Chem. 2018, 5039–5046 and “Series in Chemistry, Energy and Environment”, Eds.K. Kadish and R. Guilard, World Scientific. Vol. 5: “Bioinspired Chemistry: From Enzymes to Synthetic Models.”, Ed. M. Réglier, 2019, pp. 185-263 ; Eur. J. Inorg. Chem. 2020, 4549-4555 ; Angew. Chem. Int. Ed. Engl. 201958, 14605 –14609 and ChemBioChem 202122, 443-459.

B) [NiFe]hydrogenase (in collaboration with M. Orio, B. Faure and R. Hardré)
Biomimetic chemistry focused on functional models to perform the reversible transformation of protons to H2.

PublicationsChemCatChem 20179, 2262-2268, Eur. J. Inorg. Chem. 2018, 2259-2266 ; Chem. Eur. J. 201824, 8779-8786 ; Dalton Trans. 202049, 5064–5073 ; ChemComm 202056(75), 11106-11109.

C) Molybdenum-containing enzymes (in collaboration with O. Iranzo, M. Orio and R. Hardré) 
Biomimetic chemistry focused on functional models of Formate dehydrogenases (Fdh) that perform the reversible transformation of COinto formate.

Publication: Eur. J. Inorg. Chem. 2018, 1427-1434 and J. Org. Chem. 202186, 2210-2223.

D) Books and Chapters

  • Copper Mononuclear Monooxygenases. M. Réglier and C. Belle in “Encyclopedia of Metalloproteins”, eds. R. H. Kretsinger, V. N. Uversky and E. A. Permyakov, Springer, 2013, pp. 723-729.
  • 1-Aminocyclopropane-1-Carboxylic Acid Oxidase. A. J. Simaan and M. Réglier in "2-Oxoglutarate-Dependent Oxygenases", eds. C. Schofield and R. P. Hausinger. Royal Society of Chemistry, 2015, RSC Metallobiology Series No. 3, pp. 423-437.
  • “Bioinspired Chemistry: From Enzymes to Synthetic Models.”, Ed. M. Réglier, In “Series in Chemistry, Energy and Environment”, Eds. K. Kadish and R. Guilard, World Scientific. Vol. 5: 2019.
Collaborations et groupes

French Collaborations

Drs. Yves Le Mest and Nicolas Le Poul, CEMCA UMR CNRS 6521, Université de Bretagne Occidentale
Drs. Aurore Thibon Pourret, Hélène Jamet and Catherine Belle, DCM UMR CNRS 5250, Université Grenoble Alpes
Dr. Vincent Artero, LCBM UMR CNRS/CEA 5249, Université Grenoble Alpes
Pr. Bruno Guigliareli, BIP UMR CNRS 7281, Aix Marseille Université

Dr. Jean Guy Berrin, BBF UMR INRA, Aix Marseille Université

International Collaborations

Pr. Franc Meyer, Institut für Anorganische Chemie, Georg-August-Universität Göttingen (Germany)
Pr. Luigi Bubacco, Department of Biology, University of Padova (Italy)
Pr. Surajit Sinha, Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata (India)


Responsabilités administratives

2016-: Scientific Committee Member of the CEEBIOS (Centre Européen d'Excellence en Biomimetisme de Senlis)

2017-: Scientific Committee Member of the COSMETHICS, Cosmethics at the confluence of beauty and health (CDP 2017, Cross Disciplinary Program of Université Grenoble Alpes)

Actions de vulgarisation

Déclics: Member of the Association "Déclics" that promotes scientific research and its outlets among young people.

  • 2019 Lycées Simone Veil and Saint Exupéry (Marseille)
  • 2020 Lycée Simone Veil (Marseille)
  • 2021 Lycées Périer, Simone Veil and Thiers (Marseille)

Apprentis Chercheurs: Member of the association "Les Apprentis Chercheurs" that allows high school students to develop a research project in a research laboratory.

  • 2016/17 Skin whitening, a dangerous case of the tyrosinase inhibition
  • 2017/18 Bacteria and antibacterials
  • 2018/19 Fruit browning, ethylene and polyphenol oxidases
  • 2019/20 Copper complexes and cancers
  • 2020/21 Copper complexes and environment

Les Savanturiers: Mentoring in the association "Les Savanturiers" that mobilizes and federates schools (primary and high schools) and the scientific communities (Universities, CNRS …) to promote sciences in an educational program.

  • 2018/19 Around earthworms in the ecosystems, with the primary school Rabelais in Creil (Oise).
  • 2020/21 The world of microorganisms, with the primary school CM1/CM2 in Volonne (Alpes de Haute Provence
  • 2021/22 The world of plants, with the primary school CM1/CM2 in Volonne (Alpes de Haute Provence
Publications (89)
Reference Résumé graphique HAL

LPMO‐like activity of bioinspired copper complexes: from model substrate to extended polysaccharides

Rébecca Leblay, Rafael Delgadillo-Ruiz, Christophe Decroos, Christelle Hureau, Marius Réglier, Ivan Castillo Pérez, Bruno Faure, A. Jalila Simaan, ChemCatChem, 2023, 15, e202300933. <hal-04231361>

Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase

Elina Buitrago, Clarisse Faure, Marcello Carotti, Elisabetta Bergantino, Renaud Hardré, Marc Maresca, Christian Philouze, Nicolas Vanthuyne, Ahcène Boumendjel, Luigi Bubacco, Amaury Du Moulinet D’hardemare, Hélène Jamet, Marius Réglier, Catherine Belle, European Journal of Medicinal Chemistry, 2023, 248, 115090. <hal-03937610>

How Metal Nuclearity Impacts Electrocatalytic H2 Production in Thiocarbohydrazone-based Complexes

Michael Papadakis, Alexandre Barrozo, Léa Delmotte, Tatiana Straistari, Sergiu Shova, Marius Réglier, Vera Krewald, Sylvain Bertaina, Renaud Hardré, Maylis Orio, Inorganics, 2023, 11, 149. <hal-04061771>

Computational Insights of Selective Intramolecular O‐atom Transfer Mediated by Bioinspired Copper Complexes

Stefani Gamboa-Ramírez, Bruno Faure, M. Réglier, A. Jalila Simaan, Maylis Orio, Chemistry - A European Journal, 2022, e202202206. <hal-03789397>

Ditopic Chelators of Dicopper Centers for Enhanced Tyrosinases Inhibition

Elina Buitrago, Clarisse Faure, Lylia Challali, Elisabetta Bergantino, Ahcène Boumendjel, Luigi Bubacco, Marcello Carotti, Renaud Hardré, Marc Maresca, Christian Philouze, Hélène Jamet, Marius Réglier, Catherine Belle, Chemistry - A European Journal, 2021, 27, 4384-4393. <hal-03173336>

Synthesis of Protected 3,4- and 2,3-Dimercaptophenylalanines as Building Blocks for Fmoc -Peptide Synthesis and Incorporation of the 3,4-Analogue in a Decapeptide Using Solid-Phase Synthesis

Isita Banerjee, Keshab Ch Ghosh, Emmanuel Oheix, Marion Jean, Jean-Valère Naubron, Marius Réglier, Olga Iranzo, Surajit Sinha, Journal of Organic Chemistry, 2021, 86, 2210-2223. <hal-03359178>

Characterization of a bacterial copper‐dependent lytic polysaccharide monooxygenase with an unusual second coordination sphere

Alessia Munzone, Bilal El Kerdi, Mathieu Fanuel, Hélène Rogniaux, David Ropartz, Marius Réglier, Antoine Royant, A. Jalila Simaan, Christophe Decroos, FEBS Journal, 2020, 287, 3298-3314. <hal-02467531>

Neutral Lipophilic Palladium(II) Complexes and their Applications in Electrocatalytic Hydrogen Production and C-C Coupling Reactions

Olesea Cuzan-Munteanu, Dumitru Sirbu, Michel Giorgi, Sergiu Shova, Elizabeth A Gibson, Marius Réglier, Maylis Orio, Luísa M D R S Martins, Andrew C Benniston, European Journal of Inorganic Chemistry, 2020, 2020, 813 - 822. <hal-03009779>

Artificial enzymes for Diels‐Alder reactions

Wadih Ghattas, Jean-Pierre Mahy, Marius Réglier, A. Jalila Simaan, ChemBioChem, 2020. <hal-03098285>

Hydrogen evolution reaction mediated by an all-sulfur trinuclear nickel complex

Cyril Pieri, Anirban Bhattacharjee, Alexandre Barrozo, Bruno Faure, Michel Giorgi, Jennifer Fize, Marius Réglier, Martin Field, Maylis Orio, Vincent Artero, Renaud Hardré, Chemical Communications, 2020, 56, 11106-11109. <hal-02961657>


Chapitres d'ouvrages (3)
Reference Résumé graphique HAL

Clarisse Faure, Amaury Du Moulinet D’hardemare, Hélène Jamet, Catherine Belle, Elisabetta Bergantino, et al.. Transition State Analogue Molecules as Mechanistic Tools and Inhibitors for Tyrosinase. Copper Bioinorganic Chemistry, WORLD SCIENTIFIC, pp.45-80, 2023, ⟨10.1142/9789811269493_0002⟩. ⟨hal-04186414⟩

A. Jalila Simaan, Alda Lisa Concia, Alessia Munzone, Maria-Chrysanthi Kafentzi, Amélie Kochem, et al.. Modeling the Mononuclear Copper Monooxygenase Active Site. Series on Chemistry, Energy and the Environment: Volume 5 Bioinspired Chemistry; From Enzymes to Synthetic Models, pp.185-263, 2019, ⟨10.1142/9789813274440_0008⟩. ⟨hal-02094996⟩

A. Jalila Simaan, Marius Réglier. CHAPTER 20. 1-Aminocyclopropane-1-Carboxylic Acid Oxidase. 2-oxoglutarate-dependent oxygenases RSC Metallobiology Series, 3., pp.425-437, 2015, ⟨10.1039/9781782621959-00425⟩. ⟨hal-02095042⟩