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Portrait de Dr. Cédric Colomban
AMU iSm2 AMU ECM iSm2 Service 452
Campus Scientifique de St Jérôme
Marseille cedex 20

Bioinspired Confined Catalysis

Caged bioinorganic complexes for efficient and selective catalytic transformations in confined spaces.

Robust metal-based catalysts for efficient transformations in complex mixtures

We get inspiration from the enzyme hydrophobic pockets, to reach an efficient protection of Cu(I) catalysts. We are interrested in caged ligands that protect the Cu-center from it deactivation by the reduced gluthathione GSH, without suffering from product inhibition effect, opening the way to efficient CuAAC transformations in complex media. (Chem. Commun. 2021, 57, 2281)

 Selective C-H oxidation via caged bioinspired catalysts.

       - Bioinspired catalysis

Aiming at reproducing the remarkable chemistry found in monooxygenases enzymes, the BCC group develop bioinspired catalysts displaying a cage structure (hydrophobic cavity) that act as a filter to select the targeted substrate. In partiular we have recently demonstrated that caged catalysts results in a more selective oxidation of methane compared to the corresponding models devoid of cavity. Current research aims at developing both efficent and selective C-H oxidation methods based on caged iron and copper complexes.

       -Straightforward preparation of enantiopure caged complexes.

We develop an inovative strategy to prepare bioinspired complexes with controlled helicity. Our methodology is based on enantiopure cage-ligands displaying a chiral cap. Chirality transfer phenomenom between the northern cap and the ligand control helicity at the southern metal core. (Chem. Commun. 2019, 55, 14158).

Publications (24)
Reference Résumé graphique HAL

Bioinspired complexes confined in well-defined capsules: getting closer to metalloenzyme functionalities

Donglin Diao, A. Jalila Simaan, Alexandre Martinez, Cédric Colomban, Chemical Communications, 2023. <hal-04047768>

A caged tris(2-pyridylmethyl)amine ligand equipped with a C triazole –H hydrogen bonding cavity

Gege Qiu, Donglin Diao, Leo Chaussy, Sabine Michaud-Chevallier, A. Jalila Simaan, Paola Nava, Alexandre Martinez, Cédric Colomban, Dalton Transactions, 2022, 51, 10702-10706. <hal-03789423>

A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

Gege Qiu, Paola Nava, Alexandre Martinez, Cédric Colomban, Chemical Communications, 2021, 57, 2281-2284. <hal-03175776>

Control and Transfer of Chirality Within Well-Defined Tripodal Supramolecular Cages

Gege Qiu, Paola Nava, Cédric Colomban, Alexandre Martinez, Frontiers in Chemistry, 2020, 8. <hal-03153583>

Complete Dynamic Reconstruction of C 60 , C 70 , and (C 59 N) 2 Encapsulation into an Adaptable Supramolecular Nanocapsule

Cédric Colomban, Cristina García-Simón, Yarkin Aybars Çetin, Ana Gimeno, Míriam Pujals, Ernest Ubasart, Carles Fuertes-Espinosa, Karam Asad, Nikos Chronakis, Miquel Costas, Jesús Jiménez-Barbero, Ferran Feixas, Xavi Ribas, Journal of the American Chemical Society, 2020, 142, 16051-16063. <hal-02959688>

Highly Selective Fluoride Recognition by a Small Tris-Urea Covalent Cage

Magalie Delecluse, Cédric Colomban, Bastien Chatelet, Sabine Chevallier-Michaud, Delphine Moraleda, Jean-Pierre Dutasta, Alexandre Martinez, Journal of Organic Chemistry, 2020, 85, 4706-4711. <hal-02863548>

Mechanism of Oxidative Activation of Fluorinated Aromatic Compounds by N‐Bridged Diiron‐Phthalocyanine: What Determines the Reactivity?

Cédric Colomban, Anthonio Tobing, Gourab Mukherjee, Chivukula Sastri, Alexander Sorokin, Sam Visser, Chemistry - A European Journal, 2019, 25, 14320-14331. <hal-02381523>

Enantiopure C 1 -Cyclotriveratrylene with a Reversed Spatial Arrangement of the Substituents

Augustin Long, Cédric Colomban, Marion Jean, Muriel Albalat, Nicolas Vanthuyne, Michel Giorgi, Lorenzo Di Bari, Marcin Górecki, Jean-Pierre Dutasta, Alexandre Martinez, Organic Letters, 2019, 21, 160-165. <hal-02098280>

Chirality transfer in a cage controls the clockwise/anticlockwise propeller arrangement of the tris(2-pyridylmethyl)amine ligand

Gege Qiu, Cédric Colomban, Nicolas Vanthuyne, Michel Giorgi, Alexandre Martinez, Chemical Communications, 2019, 55, 14158-14161. <hal-02368870>

Positive Cooperative Effect in Ion‐Pair Recognition by a Tris‐urea Hemicryptophane Cage

Magalie Delecluse, Cédric Colomban, Delphine Moraleda, Innocenzo de Riggi, Françoise Duprat, Sabine Michaud-Chevallier, Jean-Pierre Dutasta, Vincent Robert, Bastien Chatelet, Alexandre Martinez, Chemistry - A European Journal, 2019, 25, 3337-3342. <hal-02098293>