Dr. Laetitia SHINTU
Dr.
Laetitia
SHINTU
AMU iSm2 Service 512
Campus Scientifique de St Jérôme
13397
Marseille cedex 20
Téléphone :
Courriel :
Parcours :
2002-2006 : Doctorat en physico-chimie et spectrométries moléculaires, Université Paul cezanne, Marseille, France
2005-2006 : ATER en chimie physique, Université Paul Cezanne, Marseille, France
2006-2008 : Postdoctorat à Institute of Food Research, Norwich, UK (Dr I. Colquhoun)
2008-2009 : Postdoctorat à l’ENS de Lyon, Villeurbanne, France (Pr. Lyndon Emsley)
2009 : Maître de Conférence/ Chaire CNRS en RMN et Métabolomique, Université Paul Cézanne, Marseille, France
Enseignements :
- Licence : chimie inorganique (TD et TP)
- Master 2 : Analyse de données (Cours)
Thématiques :
Métabolomique / Métabonomique
2012-2015 : ANR JCJC IMAPIST (porteur de projet) : Une approche Metabolomique multi-analytique et multi-compartimentée innovante préservant l'intégrité de tous les types d'échantillons (projet ANR-2011- JS08-014-01)
Responsabilités administratives :
Début
Publications (28)
Reference
Résumé graphique
HAL
An essential role of the reversible electron-bifurcating hydrogenase Hnd for ethanol oxidation in Solidesulfovibrio fructosivorans
Arlette Kpebe, Chloé Guendon, Natalie Payne, Julien Ros, Manel Khelil Berbar, Régine Lebrun, Carole Baffert, Laetitia Shintu, Myriam Brugna, Frontiers in Microbiology, 2023, 14, 1139276. <hal-04071158>
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Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis
Virginie Millet, Thomas Gensollen, Michael Maltese, Melanie Serrero, Nathalie Lesavre, Christophe Bourges, Christophe Pitaval, Sophie Cadra, Lionel Chasson, Thien Phong Vu Man, Marion Masse, Juan Jose Martinez-Garcia, Fabrice Tranchida, Laetitia Shintu, Konrad Mostert, Erick Strauss, Patricia Lepage, Mathias Chamaillard, Achille Broggi, Laurent Peyrin-Biroulet, Jean-Charles Grimaud, Philippe Naquet, Franck Galland, BMJ - British Medical Journal, 2022. <hal-03975895>
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The electron-bifurcating FeFe-hydrogenase Hnd is involved in ethanol metabolism in Desulfovibrio fructosovorans grown on pyruvate
Natalie Payne, Arlette Kpebe, Chloé Guendon, Carole Baffert, Julien Ros, Régine Lebrun, Yann Denis, Laetitia Shintu, Myriam Brugna, Molecular Microbiology, 2022. <hal-03548887>
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Identification of enriched hyperthermophilic microbial communities from a deep-sea hydrothermal vent chimney under electrolithoautotrophic culture conditions
Guillaume Pillot, Oulfat Amin Ali, Sylvain Davidson, Laetitia Shintu, Anne Godfroy, Yannick Combet-Blanc, Patricia Bonin, Pierre-Pol Liebgott, Scientific Reports, 2021, 11. <hal-03427430>
✓
Evolution of Thermophilic Microbial Communities from a Deep-Sea Hydrothermal Chimney under Electrolithoautotrophic Conditions with Nitrate
Guillaume Pillot, Oulfat Amin Ali, Sylvain Davidson, Laetitia Shintu, Yannick Combet-Blanc, Anne Godfroy, Patricia Bonin, Pierre-Pol Liebgott, Microorganisms, 2021, 9, 2475. <hal-03563636>
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Evaluation of the Rotating-Frame Relaxation ( T 1ρ ) Filter and Its Application in Metabolomics as an Alternative to the Transverse Relaxation ( T 2 ) Filter
Elena Piersanti, Lamya Rezig, Fabrice Tranchida, Wael El-Houri, Seidou Abagana, Mylène Campredon, Laetitia Shintu, Mehdi Yemloul, Analytical Chemistry, 2021, 93, 8746-8753. <hal-03655575>
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Fecal Metabolic Profiling of Breast Cancer Patients during Neoadjuvant Chemotherapy Reveals Potential Biomarkers
Oumaima Zidi, Nessrine Souai, Henda Raies, Farhat Ben Ayed, Amel Mezlini, Sonia Mezrioui, Fabrice Tranchida, Jean-Marc Sabatier, Amor Mosbah, Ameur Cherif, Laetitia Shintu, Soumaya Kouidhi, Molecules, 2021, 26, 2266. <hal-03358035>
✓
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
Rawand Masoud, Gabriela Reyes-Castellanos, Sophie Lac, Julie Garcia, Samir Dou, Laetitia Shintu, Nadine Abdel Hadi, Tristan Gicquel, Abdessamad El Kaoutari, Binta Diémé, Fabrice Tranchida, Laurie Cormareche, Laurence Borge, Odile Gayet, Eddy Pasquier, Nelson Dusetti, Juan Iovanna, Alice Carrier, Cell Reports Medicine, 2020, 1, 100143. <hal-03097443>
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Challenges in the decomposition of 2D NMR spectra of mixtures of small molecules
Afef Cherni, Elena Piersanti, Sandrine Anthoine, Caroline Chaux, Laetitia Shintu, Mehdi Yemloul, Bruno Torrésani, Faraday Discussions, 2019. <hal-02146311>
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GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors
Johanna Chiche, Julie Reverso-Meinietti, Annabelle Mouchotte, Camila Rubio-Patino, Rana Mhaidly, Elodie Villa, Jozef P. Bossowski, Emma Proics, Manuel Grima-Reyes, Agnes Paquet, Konstantina Fragaki, Sandrine Marchetti, Josette Briere, Damien Ambrosetti, Jean-Francois Michiels, Thierry Jo Molina, Christiane Copie-Bergman, Jacqueline Lehmann-Che, Isabelle Peyrottes, Frederic Peyrade, Eric De Kerviler, Bruno Taillan, Georges Garnier, Els Verhoeyen, Veronique Paquis-Flucklinger, Laetitia Shintu, Vincent Delwail, Celine Delpech-Debiais, Richard Delarue, Andre Bosly, Tony Petrella, Gabriel Brisou, Bertrand Nadel, Pascal Barbry, Nicolas Mounier, Catherine Thieblemont, Jean-Ehrland Ricci, CELL METABOLISM, 2019, 29, 1243+. <hal-02359440>
✓
Pages
Communications orales et par affiche (7)
Reference
Résumé graphique
HAL
Afef Cherni, Elena Piersanti, Sandrine Anthoine, Caroline Chaux, Laetitia Shintu, et al.. Challenges in the decomposition of 2D NMR spectra of mixtures of small molecules. Faraday Discussion Meeting, May 2019, Edinburgh, United Kingdom. ⟨hal-02371045⟩
✖
A Masion, Laetitia Shintu, Catherine Santaella. Ecotoxicity of manufactured Al nanophases. 253rd ACS National Meeting, Apr 2017, San Francisco, CA, United States. ⟨hal-03547448⟩
✖
Jean-Charles Martin, Mathieu Maillot, Gerard Mazerolles, Alexandre Verdu, Bernard Lyan, et al.. Can we Trust Untargeted Metabolomics: Results of the Metabo-ring Initiative, a Large-scale Multi-instruments Inter-laboratoire Study. 9. Annual Conference of the Metabolomics Society, Jul 2013, Glasgow, United Kingdom. 2013, 9th Annual Conference of the Metabolomics Society. ⟨hal-01123136⟩
✖
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Can we trust untargeted metabolomics: results of the metabo-ring study. 2. African-European Conference on Chemometrics - Afrodata 2012, Nov 2012, Stellenbosch, South Africa. ⟨hal-01595486⟩
✖
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Can we trust untargeted metabolomics: first results of the metabo-ring study. 8. Annual International Meeting of the Metabolomics Society, Jun 2012, Washington, United States. , 2012. ⟨hal-01595487⟩
✖
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Peut-on faire confiance à la métabolomique: résultats de l'initiative MetaboRing. 6. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), May 2012, Nantes, France. ⟨hal-01594993⟩
✖
Benjamin J. Blaise, Cécile Vercherat, V. Navratil, Annie Lacheretz-Bernigaud, Laetitia Shintu, et al.. Statistical recoupling of variables for the identification of candidate biomarkers and perturbed metabolic networks. Application to whole organism NMR. 7th International Conference of the Metabolomics Society, Jun 2011, Cairns, Australia. ⟨hal-00980051⟩
✖
Dr.
Laetitia
SHINTU
Dr.
Laetitia
SHINTU
AMU iSm2 Service 512
Campus Scientifique de St Jérôme
13397
Marseille cedex 20
Téléphone :
Courriel :
Parcours :
2002-2006 : Doctorat en physico-chimie et spectrométries moléculaires, Université Paul cezanne, Marseille, France
2005-2006 : ATER en chimie physique, Université Paul Cezanne, Marseille, France
2006-2008 : Postdoctorat à Institute of Food Research, Norwich, UK (Dr I. Colquhoun)
2008-2009 : Postdoctorat à l’ENS de Lyon, Villeurbanne, France (Pr. Lyndon Emsley)
2009 : Maître de Conférence/ Chaire CNRS en RMN et Métabolomique, Université Paul Cézanne, Marseille, France
Enseignements :
- Licence : chimie inorganique (TD et TP)
- Master 2 : Analyse de données (Cours)
Thématiques :
Métabolomique / Métabonomique
2012-2015 : ANR JCJC IMAPIST (porteur de projet) : Une approche Metabolomique multi-analytique et multi-compartimentée innovante préservant l'intégrité de tous les types d'échantillons (projet ANR-2011- JS08-014-01)
Responsabilités administratives :
Début
Publications (28)
| Reference | Résumé graphique | HAL |
|---|---|---|
|
An essential role of the reversible electron-bifurcating hydrogenase Hnd for ethanol oxidation in Solidesulfovibrio fructosivorans |
|
✓ |
|
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis |
|
✓ |
|
The electron-bifurcating FeFe-hydrogenase Hnd is involved in ethanol metabolism in Desulfovibrio fructosovorans grown on pyruvate |
|
✓ |
|
Identification of enriched hyperthermophilic microbial communities from a deep-sea hydrothermal vent chimney under electrolithoautotrophic culture conditions |
|
✓ |
|
Evolution of Thermophilic Microbial Communities from a Deep-Sea Hydrothermal Chimney under Electrolithoautotrophic Conditions with Nitrate |
|
✓ |
|
Evaluation of the Rotating-Frame Relaxation ( T 1ρ ) Filter and Its Application in Metabolomics as an Alternative to the Transverse Relaxation ( T 2 ) Filter |
|
✓ |
|
Fecal Metabolic Profiling of Breast Cancer Patients during Neoadjuvant Chemotherapy Reveals Potential Biomarkers |
|
✓ |
|
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer |
|
✓ |
|
Challenges in the decomposition of 2D NMR spectra of mixtures of small molecules |
|
✓ |
|
GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors |
|
✓ |
Pages
Communications orales et par affiche (7)
| Reference | Résumé graphique | HAL |
|---|---|---|
|
Afef Cherni, Elena Piersanti, Sandrine Anthoine, Caroline Chaux, Laetitia Shintu, et al.. Challenges in the decomposition of 2D NMR spectra of mixtures of small molecules. Faraday Discussion Meeting, May 2019, Edinburgh, United Kingdom. ⟨hal-02371045⟩ |
|
✖ |
|
A Masion, Laetitia Shintu, Catherine Santaella. Ecotoxicity of manufactured Al nanophases. 253rd ACS National Meeting, Apr 2017, San Francisco, CA, United States. ⟨hal-03547448⟩ |
|
✖ |
|
Jean-Charles Martin, Mathieu Maillot, Gerard Mazerolles, Alexandre Verdu, Bernard Lyan, et al.. Can we Trust Untargeted Metabolomics: Results of the Metabo-ring Initiative, a Large-scale Multi-instruments Inter-laboratoire Study. 9. Annual Conference of the Metabolomics Society, Jul 2013, Glasgow, United Kingdom. 2013, 9th Annual Conference of the Metabolomics Society. ⟨hal-01123136⟩ |
|
✖ |
|
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Can we trust untargeted metabolomics: results of the metabo-ring study. 2. African-European Conference on Chemometrics - Afrodata 2012, Nov 2012, Stellenbosch, South Africa. ⟨hal-01595486⟩ |
|
✖ |
|
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Can we trust untargeted metabolomics: first results of the metabo-ring study. 8. Annual International Meeting of the Metabolomics Society, Jun 2012, Washington, United States. , 2012. ⟨hal-01595487⟩ |
|
✖ |
|
Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Peut-on faire confiance à la métabolomique: résultats de l'initiative MetaboRing. 6. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), May 2012, Nantes, France. ⟨hal-01594993⟩ |
|
✖ |
|
Benjamin J. Blaise, Cécile Vercherat, V. Navratil, Annie Lacheretz-Bernigaud, Laetitia Shintu, et al.. Statistical recoupling of variables for the identification of candidate biomarkers and perturbed metabolic networks. Application to whole organism NMR. 7th International Conference of the Metabolomics Society, Jun 2011, Cairns, Australia. ⟨hal-00980051⟩ |
|
✖ |