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Dr. Alexandre Ciaccafava's picture
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
Marseille cedex 20
Date of entry
Career path
  • 2022 – present : CNRS Researcher – Institut des Science Moléculaire de Marseille, UMR 7313, Marseille, France, équipe BiosCiences.
  • 2018 – 2021: CNRS Researcher Institut de Chimie & Biologie des Membranes & des Nano-objets, UMR 5248, Bordeaux, France, équipe de Spectroscopie et Imagerie de Peptides Actifs sur les Membranes. 
  • 2013 – 2017:  Postdoc - Technische Universität Berlin – Institut für Chemie, Berlin, Germany
  • 2013: Postdoc - Laboratory of Bioenergetics and Protein Engineering, UMR 7281, Marseille, France.
  • 2009 – 2012: PhD - Laboratory of Bioenergetics and Protein Engineering, UMR 781, Marseille, France.
  • 2022: City of Marseille grant
  • 2014 - 2016:  AvH Alexander von Humboldt fellowship
  • 2013: FEBS Federation of European Biochemical Societies fellowship
  • 2013: Price of PhD, awarded by Aix-Marseille Université-AMU.
  • 2012: Price of Innovating Techniques for Environment, awarded by ADEME (Agence De l’Environnement et de la Maîtrise de l’Énergie) and POLLUTEC.
Research themes

Spectroelectrochemistry of redox enzymes

Administrative responsabilities
  • 2022 - Réferent Plinius Cursus IM2B pour l'équipe BiosCiences
Scientific outreach efforts
  • 2014: « Wie ein winziges Bakterium Kohlendioxid reduziert »TU-intern,  A.  Ciaccafava, C. Petersen.
  • 2013: « Une Biopile qui a les Watts ! », Lettre de l’AMU, E. Lojou, S. Louarn.
  • 2012: « Biopile à combustible H2/O2 pour le développement durable », E. Lojou, C. Clicquot de Mentque, Magazine Green News Techno, N°82.
Publications (24)
Reference Graphical abstract HAL

Reversible functionalization of germanium by thiol monolayers to probe protein / surface interactions by ATR-FTIR

Marion Taris, Alexandre Ciaccafava, Elisabeth Lojou, Sabine Castano, Sophie Lecomte, Vibrational Spectroscopy, 2022, 123, 103457. <hal-03836375>

Microfluidic diffusional sizing probes lipid nanodiscs formation

Mehdi Azouz, Mathilde Gonin, Sebastian Fiedler, Jonathan Faherty, Marion Decossas, Christophe Cullin, Sandrine Villette, Michel Lafleur, Isabel D. Alves, Sophie Lecomte, Alexandre Ciaccafava, Biochimica et Biophysica Acta:Biomembranes, 2020, 1862, 183215. <hal-03082923>

The large subunit of the regulatory [NiFe]-hydrogenase from Ralstonia eutropha – a minimal hydrogenase?

Giorgio Caserta, Christian Lorent, Alexandre Ciaccafava, Matthias Keck, Raffaella Breglia, Claudio Greco, Christian Limberg, Peter Hildebrandt, Stephen Cramer, Ingo Zebger, Oliver Lenz, Chemical Science, 2020, 11, 5453-5465. <hal-03079347>

Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials

Lucie Macikova, Viktor Sinica, Anna Kadkova, Sandrine Villette, Alexandre Ciaccafava, Jonathan Faherty, Sophie Lecomte, Isabel D. Alves, Viktorie Vlachova, FEBS Journal, 2019, 286, 3664-3683. <hal-03082890>

O 2 -Tolerant H 2 Activation by an Isolated Large Subunit of a [NiFe] Hydrogenase

Sven Hartmann, Stefan Frielingsdorf, Alexandre Ciaccafava, Christian Lorent, Johannes Fritsch, Elisabeth Siebert, Jacqueline Priebe, Michael Haumann, Ingo Zebger, Oliver Lenz, Biochemistry, 2018, 57, 5339-5349. <hal-02344331>

Controlling Redox Enzyme Orientation at Planar Electrodes

Vivek Pratap Hitaishi, Romain Clément, Nicolas Bourassin, Marc Baaden, Anne de Poulpiquet, Sophie Sacquin-Mora, Alexandre Ciaccafava, Elisabeth Lojou, Catalysts, 2018, 8, 192. <hal-01793660>

Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide

Alexandre Ciaccafava, Daria Tombolelli, Lilith Domnik, Jae-Hun Jeoung, Holger Dobbek, Maria-Andrea Mroginski, Ingo Zebger, Peter Hildebrandt, Angewandte Chemie International Edition, 2017, 56, 7398-7401. <hal-03079320>

Efficiency of Enzymatic O2 Reduction by Myrothecium verrucaria Bilirubin Oxidase Probed by Surface Plasmon Resonance, PMIRRAS, and Electrochemistry

Cristina Gutierrez-Sanchez, Alexandre Ciaccafava, Pierre-Yves Blanchard, Karen Monsalve, Marie-Thérèse Giudici-Orticoni, Sophie Lecomte, E. Lojou, ACS Catalysis, 2016, 6, pp 5482–5492. <hal-01405977>

When the inhibitor tells more than the substrate: the cyanide-bound state of a carbon monoxide dehydrogenase

Alexandre Ciaccafava, Daria Tombolelli, Lilith Domnik, Jochen Fesseler, Jae-Hun Jeoung, Holger Dobbek, Maria Andrea Mroginski, Ingo Zebger, Peter Hildebrandt, Chemical Science, 2016, 7, 3162-3171. <hal-03079306>

The weak, fluctuating, dipole moment of membrane-bound hydrogenase from Aquifex aeolicus accounts for its adaptability to charged electrodes

Francesco Oteri, Alexandre Ciaccafava, Anne De Poulpiquet, Marc Baaden, Elisabeth. Lojou, Sophie Sacquin-Mora, Physical Chemistry Chemical Physics, 2014, 16, 11318-11322. <hal-01493492>


Oral or poster communication (2)
Reference Graphical abstract HAL

Lucie Macikova, Viktor Sinica, Anna Kadkova, Sandrine Villette, Alexandre Ciaccafava, et al.. Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials. Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Jul 2019, Madrid, Spain. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 48, pp.S170-S170. ⟨hal-02381213⟩

Francesco Oteri, Anne de Poulpiquet, Alexandre Ciaccafava, Elisabeth Lojou, Marc Baaden. Molecular Modeling of Hydrogenase Enzymes for Biofuel Cell Design. 57th Annual Meeting of the Biophysical-Society, Feb 2013, Philadelphia, United States. pp.335a, ⟨10.1016/j.bpj.2012.11.1864⟩. ⟨hal-03079239⟩

Chapters of books (1)
Reference Graphical abstract HAL

Marianne Guiral, Laurence Prunetti, Clément Aussignargues, Alexandre Ciaccafava, Pascale Infossi, et al.. The Hyperthermophilic Bacterium Aquifex aeolicus: From Respiratory Pathways to Extremely Resistant Enzymes and Biotechnological Applications. ADVANCES IN BACTERIAL RESPIRATORY PHYSIOLOGY, pp.125-194, 2012, ⟨10.1016/B978-0-12-394423-8.00004-4⟩. ⟨hal-03079147⟩