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Dr. Nicolas Vanthuyne's picture
AMU iSm2 Service 432
Campus Scientifique de St Jérôme
Marseille cedex 20
Phone number

Career path

2004 Doctorat de chimie organique (Université “Paul Cézanne”, Aix-Marseille III)
2000 Ingénieur ENSSPICAM (Ecole Nationale Supérieure de Synthèses, de Procédés et d'Ingénierie d'Aix-Marseille) et Diplôme d’Etudes Approfondies de Chimie et Physico-Chimie Moléculaire Organique (Université “Paul Cézanne”, Aix-Marseille III)

Research themes

Séparations analytiques et préparatives d’énantiomères par chromatographie liquide chirale
Stéréochimie dynamique

Publications (247)
Reference Graphical abstract HAL

Synthesis of chiral primary amines: diastereoselective alkylation of N-[(1E)-alkylidene]-3,5-bis[(1S)-1-methoxyethyl]-4H-1,2,4-triazol-4-amines and N4-Nexocyclic bond cleavage in the resulting 1,2,4-triazol-4-alkylamines.

M. Serradeil-Albalat, C. Roussel, N. Vanthuyne , J.-C. Vallejos , D. Wilhem, Tetrahedron : Asymmetry, 2008, 19 :2682-2692.

Update method for the chromatographic resolution of chiral diacylglycerols and analysis of the stereoselective hydrolysis of triacylglycerols by lipases

J. A. Rodriguez, L. D. Mendoza, F. Pezzotti, N. Vanthuyne, J. Leclaire, R.Verger, G. Buono, F. Carriere, F. Fotiadu, Anal. Biochem. 2008, 375, 196.

Novel chromatographic resolution of chiral diacylgkycerols and analysis of the stereoselective hydrolysis of triacylglycerols by lipases

J. A. Rodriguez, L. D. Mendoza, F. Pezotti, N. Vanthuyne, J. Leclaire, R. Verger, G. Buono, F. Carriere, F. Fotiadu Analytical Biochemistry 2008, 375, 196-208

Atropisomerism in the 2-Arylimino-N-(2-hydroxyphenyl)thiazoline Series: Influence of Hydrogen Bonding on the Racemization Process.

C. Roussel,, N. Vanthuyne, M. Bouchekara,, A. Djafri, J. Elguero,, I. Alkorta, Journal of Organic Chemistry 2008, 73, 403-411.

N-Acyl glycinates as acyl donors in serine protease-catalyzed kinetic resolution of amines. Improvement of selectivity and reaction rate

Malek Nechab, Lahssen El Blidi, Nicolas Vanthuyne, Stéphane Gastaldi, Michèle P. Bertrand, Gérard Gil, Organic and Biomolecular Chemistry, 2008, 6, 3917. <hal-02517472>

Chemoenzymatic synthesis of novel adenosine carbanucleoside analogues containing a locked 3’-methyl-2’,3’-beta-oxirane-fused system

Y. Aubin, G. Audran, N. Vanthuyne, H. Monti, Tetrahedron 2007, 63, 2050-5055

HPLC on chiral support with polarimetric detection: application to conglomerate discovery.

C. Roussel, N. Vanthuyne, J-L, Jobert, A. I. Loas, A. E. Tanase, D. Gherase, Chirality, 2007, 19, 497-502.

Highly Selective Enzymatic Kinetic Resolution of Primary Amines at 80 °C: A Comparative Study of Carboxylic Acids and Their Ethyl Esters as Acyl Donors

M. Nechab, N. Azzi, N. Vanthuyne, M. Bertrand, S. Gastaldi, and G. Gil, , J. Org. Chem. 2007, 72, 6918-6923

Dynamic Kinetic Resolution of Amines Involving Biocatalysis and in Situ Free Radical Mediated Racemization

S. Gastaldi, S. Escoubet, N. Vanthuyne, G. Gil, and M. P. Bertrand, , Organic Letters 2007 9, 837-839

HPLC separation and VCD spectroscopy of chiral pyrazoles derived from (5R)-dihydrocarvone.

E. Tur, G. Vives, G. Rapenne, J. Crassous, N. Vanthuyne, C. Roussel, R. Lombardi, T. Freedman, L. Nafie, Tetrahedron : Asymmetry 2007, 18, 1911-1917.


Oral or poster communication (3)
Reference Graphical abstract HAL

Kais Dhbaibi, Monika Srebro-Hooper, Philippe Blanchard, Clément Cabanetos, Nicolas Vanthuyne, et al.. Design d’émetteurs hélicèniques pour l’élaboration d’OLEDs chirales. Science et Technologie des systèmes Pi-Conjugués (SPIC), Oct 2019, Arras, France. ⟨hal-02922011⟩

Cécile Mézière, Magali Allain, Cristina Oliveras-Gonzalez, Thomas Cauchy, Nicolas Vanthuyne, et al.. Tetrathiafulvalene-[2.2]paracyclophanes: Synthesis, chiral structures and chiroptical properties. Journées André Collet de la Chiralité, 2018, Noirmoutier, France. 2018. ⟨hal-02564566⟩

Ludovic Favereau, Monika Srebro-Hooper, Francesco Zinna, Philippe Blanchard, Clément Cabanetos, et al.. Matériaux moléculaires chiraux pour l'optoélectronique. SPIC 2017, Oct 2017, Limoges, France. ⟨hal-02888985⟩

Chapters of books (2)
Reference Graphical abstract HAL

Nicolas Vanthuyne, Christian Roussel. Chiroptical Detectors for the Study of Unusual Phenomena in Chiral Chromatography. Topics in Current Chemistry, Differentiation of Enantiomers I, pp.107-151, 2013, ⟨10.1007/128_2013_441⟩. ⟨hal-02528021⟩

Ibon Alkorta, José Elguero, Christian Roussel, Nicolas Vanthuyne, Patrick Piras. Atropisomerism and Axial Chirality in Heteroaromatic Compounds. Advances in Heterocyclic Chemistry, 105, pp.1-188, 2012, ⟨10.1016/B978-0-12-396530-1.00001-2⟩. ⟨hal-02517553⟩