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Dr. Yasmina Mekmouche's picture
AMU iSm2 Service 342
Campus Scientifique de St Jérôme
Marseille cedex 20
Phone number
Date of entry
PhD submission
PhD supervisor
Dr. Stéphane Ménage & Pr. Marc Fontecave
PhD subject
Oxydations d'alcanes et de sulfures par des hydroperoxydes catalysées par des complexes de fer : vers une chimie centrée sur le métal
Career path

2018 Habilitation, UMR 7313 - iSm2 (AMU), with Dr. Thierry Tron

2004 Researcher at CNRS, UMR 7313 - iSm2 (AMU), with Dr. Marius Réglier

2003-2004 Post-doc research associate, Laboratoire de Chimie de Coordination (LCC), Toulouse, France, with Prof. P. Faller

2002-2003 Post-doc research associate, University of Minnesota, Minneapolis, Mn, USA, with Prof. John D. Lipscomb

1997-2001 MSc in molecular chemistry (honors) then Ph.D. in molecular chemistry with Prof. M. Fontecave and Dr. S. Ménage, Grenoble Alpes University

1993-1997 2-year courses in general sciences, 2-year specialization in biochemistry


Since 2016 Member of the scientific committee of international congress Oxizymes  (stimulate scientific research on the discovery and mode of action of oxidoreductases and their industrial applications).


Since 2017 Practical courses in Analytical Chemistry, IUT Chemistry (AMU) (25 h/year)

Since 2018 Courses at school of INSERM, Liliane Bettencourt, Paris (3h/year)

Research themes

Development of artificial metalloenzymes for catalysis.

  • Production of laccases and variants
  • Photoinduced catalysis
  • Aerobic oxidation : alcohol oxidation/ aza Wacker oxidation
  • Development of heterogeneous hybrid catalysts


Collaborations and groups

National Collaborations

Pr. Ally Aukauloo, Dr. Winfried Leibl, Dr. Frédéric Banse (CEA, Université Paris Saclay)

Pr. Rénal Backov (Université Bordeaux/CNRS)

Pr. Eric Deniau (Université Lille) 

Dr Sylvain Bertaina (Aix Marseille Université)

Dr Florence Chapsoul (Aix Marseille Université)

International Collaborations

Pr. Athanassios G. Coustoulelos, (U of Crete,Heraklion, Grece )

Pr. Victor Guallar, (Barcelone University, Spain) 

Dr. MARTÍNEZ-MORALES, Fernando, DR. -Trejo-Hernández, María Refugio (Universidad Autónoma del Estado de Morelos , Mexico)

Pr. Franck Hollmann (Delft University, Netherlands)

Administrative responsabilities

2008-2012 Membre élue du conseil du département de biologie

2014-2017 Membre élue au conseil de laboratoire (iSm2))

Scientific outreach efforts

2017 European Night of researcher

Since 2016 Young researcher training with Association L’arbre des Connaissances

Publications (29)
Reference Graphical abstract HAL

Gram-scale production of a basidiomycetous laccase in Aspergillus niger

Yasmina Mekmouche, Simeng Zhou, Angela M Cusano, Eric Record, Anne Lomascolo, Viviane Robert, a Jalila Simaan, Pierre Rousselot-Pailley, Sana Ullah, Florence Chaspoul, Thierry Tron, Journal of Bioscience and Bioengineering, 2014, 117, 1-3. <hal-01268150>

Visible Light-Driven O 2 Reduction by a Porphyrin–Laccase System

Theodore Lazarides, Igor Sazanovich, A. Jalila Simaan, Maria Kafentzi, Milan Delor, Yasmina Mekmouche, Bruno Faure, Julia Weinstein, Athanassios Coutsolelos, Thierry Tron, Maria Chrisanthi Kafentzi, Marius Réglier, Journal of the American Chemical Society, 2013, 135, 3095-3103. <hal-02091417>

Photoinduced Multielectron Transfer to a Multicopper Oxidase Resulting in Dioxygen Reduction into Water

A. Jalila Simaan, Yasmina Mekmouche, Christian Herrero, Pierre Moreno, Ally Aukauloo, Jacques Delaire, Marius Réglier, Thierry Tron, Chemistry - A European Journal, 2011, 17, 11743-11746. <hal-02096695>

1-Plasticity of laccase generated by homeologous recombination in yeast.

A. M. Cusano, Y. Mekmouche, M. Meglecz, T.Tron(2009) FEBS J. 276, 5471-5480.

Identification of a Copper(I) Intermediate in the Conversion of 1-Aminocyclopropane Carboxylic Acid (ACC) into Ethylene by Cu(II)−ACC Complexes and Hydrogen Peroxide

Wadih Ghattas, Michel Giorgi, Yasmina Mekmouche, Tsunehiro Tanaka, Antal Rockenbauer, M. Réglier, Yutaka Hitomi, A. Jalila Simaan, Inorganic Chemistry, 2008, 47, 4627-4638. <hal-01948939>


Chapters of books (1)
Reference Graphical abstract HAL

Simeng Zhou, Pierre Rousselot-Pailley, Lu Ren, Yolande Charmasson, Elise Courvoisier Dezord, et al.. Production and manipulation of blue copper oxidases for technological applications. Methods in Enzymology, pp.17-61, 2018, ⟨10.1016/bs.mie.2018.10.015⟩. ⟨hal-02396850⟩